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当合成生物学遇上医学。

When synthetic biology meets medicine.

作者信息

Feng Yuge, Su Cong, Mao Guobin, Sun Baoting, Cai Yizhi, Dai Junbiao, Ma Yingxin

机构信息

CAS Key Laboratory of Quantitative Engineering Biology, Guangdong Provincial Key Laboratory of Synthetic Genomics and Shenzhen Key Laboratory of Synthetic Genomics, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.

Department of Biochemistry and Molecular Biology, College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.

出版信息

Life Med. 2024 Mar 6;3(1):lnae010. doi: 10.1093/lifemedi/lnae010. eCollection 2024 Feb.

Abstract

In recent years, the world has faced significant challenges with the coronavirus disease 2019 (COVID-19) pandemic, as well as other infectious diseases such as Zika and Ebola. Furthermore, the rapid rise of non-communicable diseases such as diabetes, heart disease, and cancer has placed tremendous strain on healthcare resources and systems. Unfortunately, advancements in drug development, diagnostics, and therapeutics have struggled to keep pace with the emergence and progression of diseases, necessitating the exploration of new technologies for the discovery and development of biomedicines and biotherapies. Synthetic biology, a revolutionary field in modern science, holds great promise in advancing drug development and disease treatment. This review provides a comprehensive overview of recent developments in the application of synthetic biology to medicine, with a specific focus on its role in drug discovery, drug production, and the diagnosis and treatment of various diseases.

摘要

近年来,世界面临着2019冠状病毒病(COVID-19)大流行以及寨卡和埃博拉等其他传染病带来的重大挑战。此外,糖尿病、心脏病和癌症等非传染性疾病的迅速增加给医疗资源和系统带来了巨大压力。不幸的是,药物开发、诊断和治疗方面的进展难以跟上疾病的出现和发展,因此有必要探索用于发现和开发生物药物及生物疗法的新技术。合成生物学作为现代科学中的一个革命性领域,在推进药物开发和疾病治疗方面具有巨大潜力。本综述全面概述了合成生物学在医学应用方面的最新进展,特别关注其在药物发现、药物生产以及各种疾病的诊断和治疗中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99a6/11749639/4d1ac33c12d7/lnae010_fig1.jpg

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