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Defining the path to hematopoietic stem cells.

作者信息

Sturgeon Christopher M, Ditadi Andrea, Clarke Raedun L, Keller Gordon

机构信息

McEwen Centre for Regenerative Medicine, University Health Network, Toronto, Ontario, Canada.

出版信息

Nat Biotechnol. 2013 May;31(5):416-8. doi: 10.1038/nbt.2571.

DOI:10.1038/nbt.2571
PMID:23657396
Abstract
摘要

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Hemogenic endothelium: a vessel for blood production.血发生内皮：造血的血管。
Int J Biochem Cell Biol. 2013 Mar;45(3):692-5. doi: 10.1016/j.biocel.2012.12.013. Epub 2012 Dec 25.
2
Signaling axis involving Hedgehog, Notch, and Scl promotes the embryonic endothelial-to-hematopoietic transition.涉及 Hedgehog、Notch 和 Scl 的信号轴促进胚胎内皮细胞向造血细胞的转变。
Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):E141-50. doi: 10.1073/pnas.1214361110. Epub 2012 Dec 12.
3
T lymphocyte potential marks the emergence of definitive hematopoietic progenitors in human pluripotent stem cell differentiation cultures.
In vitro vascular differentiation system efficiently produces natural killer cells for cancer immunotherapies.
体外血管分化系统高效产生自然杀伤细胞用于癌症免疫疗法。
Oncoimmunology. 2023 Sep 12;12(1):2240670. doi: 10.1080/2162402X.2023.2240670. eCollection 2023.
4
Induced Pluripotent Stem Cells as a Tool for Modeling Hematologic Disorders and as a Potential Source for Cell-Based Therapies.诱导多能干细胞作为建模血液系统疾病的工具和细胞治疗的潜在来源。
Cells. 2021 Nov 19;10(11):3250. doi: 10.3390/cells10113250.
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Single-Cell Approaches to Deconvolute the Development of HSCs.单细胞方法解析造血干细胞的发育。
Cells. 2021 Oct 25;10(11):2876. doi: 10.3390/cells10112876.
6
A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy.从 iPS 细胞中生成 T 细胞的一种临床适用且可扩展的方法，用于现成的 T 细胞免疫疗法。
Nat Commun. 2021 Jan 18;12(1):430. doi: 10.1038/s41467-020-20658-3.
7
MYB bi-allelic targeting abrogates primitive clonogenic progenitors while the emergence of primitive blood cells is not affected.MYB双等位基因靶向消除原始克隆形成祖细胞，而原始血细胞的出现不受影响。
Haematologica. 2021 Aug 1;106(8):2191-2202. doi: 10.3324/haematol.2020.249193.
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Vitamin C-dependent lysine demethylase 6 (KDM6)-mediated demethylation promotes a chromatin state that supports the endothelial-to-hematopoietic transition.维生素 C 依赖性赖氨酸去甲基酶 6（KDM6）介导的去甲基化促进了支持内皮细胞向造血细胞转变的染色质状态。
J Biol Chem. 2019 Sep 13;294(37):13657-13670. doi: 10.1074/jbc.RA119.009757. Epub 2019 Jul 24.
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Expanded potential stem cell media as a tool to study human developmental hematopoiesis in vitro.扩展潜能干细胞培养液作为一种体外研究人类发育性造血的工具。
Exp Hematol. 2019 Aug;76:1-12.e5. doi: 10.1016/j.exphem.2019.07.003. Epub 2019 Jul 18.
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Cell Rep. 2012 Dec 27;2(6):1722-35. doi: 10.1016/j.celrep.2012.11.003. Epub 2012 Dec 7.
4
Human ESC-derived hemogenic endothelial cells undergo distinct waves of endothelial to hematopoietic transition.人类胚胎干细胞来源的造血内皮细胞经历了不同的内皮向造血转化波。
Blood. 2013 Jan 31;121(5):770-80. doi: 10.1182/blood-2012-07-444208. Epub 2012 Nov 20.
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Role of SOX17 in hematopoietic development from human embryonic stem cells.SOX17 在人胚胎干细胞造血发育中的作用。
Blood. 2013 Jan 17;121(3):447-58. doi: 10.1182/blood-2012-05-431403. Epub 2012 Nov 20.
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The biochemistry of hematopoietic stem cell development.造血干细胞发育的生物化学
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Identification of the hemogenic endothelial progenitor and its direct precursor in human pluripotent stem cell differentiation cultures.鉴定人多能干细胞分化培养中的造血内皮祖细胞及其直接前体细胞。
Cell Rep. 2012 Sep 27;2(3):553-67. doi: 10.1016/j.celrep.2012.08.002. Epub 2012 Sep 13.
9
Dual lineage-specific expression of Sox17 during mouse embryogenesis. Sox17 在小鼠胚胎发生过程中的双谱系特异性表达。
Stem Cells. 2012 Oct;30(10):2297-308. doi: 10.1002/stem.1192.
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Embryonic origin of the adult hematopoietic system: advances and questions.成人造血系统的胚胎起源：进展与问题。
Development. 2011 Mar;138(6):1017-31. doi: 10.1242/dev.040998.