Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
J Clin Microbiol. 2013 Jul;51(7):2427-31. doi: 10.1128/JCM.00489-13. Epub 2013 May 8.
The population structure of 3,776 Mycobacterium tuberculosis isolates was determined using variable-number tandem-repeat (VNTR) typing. The degree of clonality was so high that a more relaxed definition of clustering cannot be applied. Among recent immigrants with non-Euro-American isolates, transmission is overestimated if based on identical VNTR patterns.
采用可变数目串联重复(VNTR)分型方法,对 3776 株结核分枝杆菌分离株的种群结构进行了分析。由于其克隆程度如此之高,因此不能采用更宽松的聚类定义。在非欧洲裔美国人分离株的近期移民中,如果根据相同的 VNTR 模式来推断传播,那么传播会被高估。