School of Public Health-Bloomington, Department of Kinesiology, Human Performance and Exercise Biochemistry Laboratory, 1025 E. 7th St. SPH 112, Bloomington, IN 47404, USA.
Respir Med. 2013 Aug;107(8):1152-63. doi: 10.1016/j.rmed.2013.04.010. Epub 2013 May 7.
Evaluate the effect of the marine lipid fraction of the New Zealand green-lipped mussel (Perna canaliculus) PCSO-524 (Lyprinol/Omega XL), rich in omega-3 fatty acids, on airway inflammation and the bronchoconstrictor response to eucapnic voluntary hyperpnea (EVH) in asthmatics.
Twenty asthmatic subjects, with documented HIB, participated in a placebo controlled double-blind randomized crossover trial. Subjects entered the study on their usual diet and were then placed on 3 weeks of PCSO-524 or placebo supplementation, followed by a 2 week washout period, before crossing over to the alternative diet. Pre- and post-eucapnic voluntary hyperpnea (EVH) pulmonary function, fraction of exhaled nitric oxide (FENO), asthma symptom scores, medication use, exhaled breath condensate (EBC) pH, cysteinyl leukotrienes (cyst-LT), 8-isoprostane and urinary 9α, 11β-prostaglandin (PG)F2 and Clara (CC16) protein concentrations were assessed at the beginning of the trial and at the end of each treatment period.
The PCSO-524 diet significantly reduced (p < 0.05) the maximum fall in post-EVH FEV1 (-8.4 ± 3.2%) compared to usual (-19.3 ± 5.4%) and placebo diet (-22.5 ± 13.7%). Pre- and post- EVH EBC cyst-LT and 8-isoprostane, and urinary 9α, 11β-PGF2 and CC16 concentrations were significantly reduced (p < 0.05) on the PCSO-524 diet compared to the usual and placebo diet. EBC pH and asthma symptom scores were significantly improved (p < 0.05) and rescue medication use significantly reduced (p < 0.05) on the PCSO-524 diet compared to the usual and placebo diet.
PCSO-524 (Lyprinol)/Omega XL) may have beneficial effects in HIB and asthma by serving as a pro-resolving agonist and/or inflammatory antagonist.
评估富含 ω-3 脂肪酸的新西兰绿唇贻贝（Perna canaliculus）PCS0-524（利嘌醇/欧米伽 XL）的海洋脂质部分对哮喘患者气道炎症和对呼气末正压通气（EVH）的支气管收缩反应的影响。
20 名哮喘患者有明确的 HIB 病史，参加了一项安慰剂对照双盲随机交叉试验。受试者在常规饮食下进入研究，然后接受 3 周的 PCS0-524 或安慰剂补充治疗，然后进入 2 周的洗脱期，然后再交叉到另一种饮食。在试验开始时和每个治疗期结束时，评估了基础呼气末正压通气（EVH）肺功能、呼出一氧化氮分数（FENO）、哮喘症状评分、药物使用、呼气冷凝液（EBC）pH 值、半胱氨酰白三烯（cyst-LT）、8-异前列腺素和尿 9α、11β-前列腺素（PG）F2 和 Clara（CC16）蛋白浓度。
与常规饮食（-19.3 ± 5.4%）和安慰剂饮食（-22.5 ± 13.7%）相比，PCS0-524 饮食显著降低了 EVH 后 FEV1 的最大下降（p < 0.05）（-8.4 ± 3.2%）。与常规饮食和安慰剂饮食相比，PCS0-524 饮食显著降低了预 EVH 和 EVH 后 EBC 半胱氨酰白三烯和 8-异前列腺素以及尿 9α、11β-PGF2 和 CC16 浓度（p < 0.05）。与常规饮食和安慰剂饮食相比，PCS0-524 饮食显著改善了 EBC pH 值和哮喘症状评分（p < 0.05），并显著减少了急救药物的使用（p < 0.05）。
PCS0-524（利嘌醇/欧米伽 XL）可能作为一种促解决激动剂和/或炎症拮抗剂，对 HIB 和哮喘有有益的作用。
