Emelyanov A, Fedoseev G, Krasnoschekova O, Abulimity A, Trendeleva T, Barnes P J
Hospital Therapeutic Clinic, Pavlov Medical University, St-Petersburg. Russia.
Eur Respir J. 2002 Sep;20(3):596-600. doi: 10.1183/09031936.02.02632001.
Asthma is a chronic inflammatory disease of the airways mediated, at least in part, by leukotrienes and other lipid mediators. Experimental studies have shown that lipid extract of New Zealand green-lipped mussel, Perna canaliculus, is effective in inhibiting 5'-lipoxygenase and cyclo-oxygenase pathways responsible for production of eicosanoids, including leukotrienes and prostaglandins. The aim of this study was to assess its effect on symptoms, peak expiratory flow (PEF) and hydrogen peroxide (H2O2) in expired breath condensate as a marker of airway inflammation in patients with steroid-naïve atopic asthma in a double-blind randomised, placebo-controlled clinical trial. Forty six patients with atopic asthma received two capsules of lipid extract (Lyprinol) or placebo b.i.d for 8 weeks. Each capsule of lipid extract contained 50 mg omega-3 polyunsaturated fatty acids and 100 mg olive oil, whereas placebo capsules contained only 150 mg olive oil. There was a significant decrease in daytime wheeze, the concentration of exhaled H2O2 and an increase in morning PEF in the lipid extract group compared to the placebo group. There were no significant side-effects. The authors conclude that lipid extract of New Zealand green-lipped mussel may have some beneficial effect in patients with atopic asthma.
哮喘是一种气道慢性炎症性疾病，至少部分由白三烯和其他脂质介质介导。实验研究表明，新西兰绿唇贻贝（Perna canaliculus）的脂质提取物可有效抑制负责产生类二十烷酸（包括白三烯和前列腺素）的5'-脂氧合酶和环氧化酶途径。本研究的目的是在一项双盲随机、安慰剂对照的临床试验中，评估其对初治特应性哮喘患者症状、呼气峰值流速（PEF）以及呼出气冷凝物中过氧化氢（H2O2）作为气道炎症标志物的影响。46例特应性哮喘患者接受脂质提取物（Lyprinol）胶囊或安慰剂，每日两次，共8周。脂质提取物胶囊每粒含50mgω-3多不饱和脂肪酸和100mg橄榄油，而安慰剂胶囊仅含l50mg橄榄油。与安慰剂组相比，脂质提取物组白天喘息、呼出H2O2浓度显著降低，晨间PEF升高。无明显副作用。作者得出结论，新西兰绿唇贻贝的脂质提取物可能对特应性哮喘患者有一些有益作用。
