Akay Olga Meltem, Karagulle Mustafa, Kus Gokhan, Mutlu Fezan Sahın, Gunduz Eren
Department of Hematology, Eskişehir Osmangazi University Medical School, Eskisehir 26480, Turkey.
Transfus Apher Sci. 2013 Jun;48(3):387-90. doi: 10.1016/j.transci.2013.04.023. Epub 2013 May 6.
Rotation thrombelastogram (ROTEM®/TEG®) assays allow rapid global assessment of hemostatic function using whole blood. Since published data about the effects of automated red cell collection on coagulation system are scarce, we aimed to investigate the effects of 2-RBC apheresis on donor's coagulation system using ROTEM® assays. In INTEM assay, CFT was significantly shortened 24h after apheresis compared with baseline value (p<0.05) and MCF was significantly prolonged immediately after apheresis and 24h after apheresis compared with baseline value (p<0.05 and p<0.01, respectively). In EXTEM assay, CFT was significantly prolonged immediately after apheresis and 24h after apheresis compared with baseline value (p=0.001 and p<0.001, respectively) and MCF was significantly prolonged 24h after apheresis compared with baseline value (p<0,001). Our results demonstrate thromboelastographic signs of hypercoagulability in donors undergoing 2-RBC apheresis.
旋转血栓弹力图（ROTEM®/TEG®）检测可使用全血对止血功能进行快速全面评估。由于关于自动红细胞采集对凝血系统影响的已发表数据较少，我们旨在使用ROTEM®检测来研究两次红细胞单采对献血者凝血系统的影响。在INTEM检测中，与基线值相比，单采后24小时的凝血形成时间（CFT）显著缩短（p<0.05），且与基线值相比，单采后即刻及单采后24小时的最大凝血块硬度（MCF）显著延长（分别为p<0.05和p<0.01）。在EXTEM检测中，与基线值相比，单采后即刻及单采后24小时的CFT显著延长（分别为p = 0.001和p<0.001），且与基线值相比，单采后24小时的MCF显著延长（p<0.001）。我们的结果显示，接受两次红细胞单采的献血者存在血栓弹力图高凝迹象。
