Arabul Mahmut, Celik Mustafa, Aslan Ozgur, Torun Serkan, Beyazit Yavuz, Alper Emrah, Kandemir Altay, Ünsal Belkis
Department of Gastroenterology, Izmir Katip Celebi University, Atatürk Training and Research Hospital, Izmir, Turkey.
Hepatogastroenterology. 2013 May;60(123):595-600. doi: 10.5754/hge12770.
BACKGROUND/AIMS: Predicting the severity of acute pancreatitis is limited to clinical, laboratory and radiological risk factors. Hepcidin levels increase in acute inflammation. We aimed to assess the relationship between hepcidin and C-reactive protein (CRP), white blood cells (WBC) and multi-detector computerized tomography (MDCT) in predicting the severity of pancreatitis.
We undertook a prospective review of 59 consecutive patients with acute pancreatitis admitted to our clinic. Biochemical values were measured from blood samples taken within 2 hours of admission and from between 2 and 72 hours related to the time of symptom onset.
In predicting severe acute pancreatitis, hepcidin was superior to CRP and WBC (Area Under the Curve (AUC)=0.79, p=0.003; AUC=0.69, p=NS; AUC=0.53, p=NS, respectively).
In this study, hepcidin was found to be superior to CRP in predicting the severity of pancreatitis.
背景/目的：预测急性胰腺炎的严重程度仅限于临床、实验室和放射学危险因素。急性炎症时铁调素水平会升高。我们旨在评估铁调素与C反应蛋白（CRP）、白细胞（WBC）以及多排螺旋计算机断层扫描（MDCT）在预测胰腺炎严重程度方面的关系。
我们对连续收治入我院的59例急性胰腺炎患者进行了前瞻性研究。在入院后2小时内以及症状出现后2至72小时采集血样，测定生化值。
在预测重症急性胰腺炎方面，铁调素优于CRP和WBC（曲线下面积（AUC）分别为0.79，p = 0.003；0.69，p无统计学意义；0.53，p无统计学意义）。
在本研究中，发现铁调素在预测胰腺炎严重程度方面优于CRP。
