Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, PR China.
Planta Med. 2013 May;79(8):673-9. doi: 10.1055/s-0032-1328541. Epub 2013 May 13.
Four new triterpenoid saponins named clematangosides A-D (1-4) along with six known saponins (5-10) were isolated from the whole plants of Clematis tangutica. Their structures were determined by extensive spectral analysis and chemical evidences. All saponins were evaluated for their protective effects in hypoxia-induced myocardial injury model. Compounds 2-4, 6, and 10 exhibited anti-myocardial ischemia activities with ED50 values in the range of 75.77-127.22 µM.
从川滇铁线莲全株中分离得到了 4 个新的三萜皂苷，分别命名为 clematangosides A-D（1-4），以及 6 个已知的皂苷（5-10）。通过广泛的光谱分析和化学证据确定了它们的结构。所有皂苷都进行了缺氧诱导心肌损伤模型的保护作用评价。化合物 2-4、6 和 10 具有抗心肌缺血活性，ED50 值在 75.77-127.22µM 范围内。
