Department of Pharmacy, People's Liberation Army Institute of Chinese Medicine, Beijing 100039, China.
People's Liberation Army Institute of Organ Transplantation, Beijing 100091, China.
Molecules. 2018 Feb 23;23(2):491. doi: 10.3390/molecules23020491.
Five previously undescribed triterpenoid saponins (-), along with eight known ones (-), were isolated from the whole plants of var. . Their structures were clarified by extensive spectroscopic data and chemical evidence. For the first time, the lupane-type saponins ( and ) were reported from the genus. The anti-proliferative activity of all isolated saponins was evaluated on hepatic stellate cells (HSC-T6). Saponins and , which possess more monosaccharides than the others, displayed potent anti-proliferative activity, with IC values of 18.21 and 15.56 μM, respectively.
从 var. 的全株植物中分离得到了五个以前未描述的三萜皂苷（-）和八个已知的（-）。通过广泛的光谱数据和化学证据阐明了它们的结构。首次从 属中报道了羽扇豆烷型皂苷（和）。所有分离出的皂苷均在肝星状细胞（HSC-T6）上进行了抗增殖活性评估。具有比其他皂苷更多单糖的皂苷 和 ，表现出很强的抗增殖活性，IC 值分别为 18.21 和 15.56 μM。
