Miles Anna, Zeng Irene S L, McLauchlan Helen, Huckabee Maggie-Lee
Department of Communication Disorders, The University of Canterbury, 66 Stewart St, Christchurch 8011, New Zealand ; Speech Science, School of Psychology, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
J Clin Med Res. 2013 Jun;5(3):222-33. doi: 10.4021/jocmr1340w. Epub 2013 Apr 23.
Significant health issues and service delivery costs are associated with post-stroke pneumonia related to dysphagia. Silent aspiration is known to increase pneumonia and mortality in this population. The utility of cough reflex testing (CRT) for reducing pneumonia in acute stroke patients was the subject of this randomised, controlled trial.
Patients referred for swallowing evaluation (N = 311) were assigned to either 1) a control group receiving standard evaluation or 2) an experimental group receiving standard evaluation with CRT. Participants in the experimental group were administered nebulised citric acid with test results contributing to clinical decisions. Outcomes for both groups were measured by pneumonia rates at 3 months post evaluation and other clinical indices of swallowing management.
Analysis of the data identified no significant differences between groups in pneumonia rate (P = 0.38) or mortality (P = 0.15). Results of CRT were shown to influence diet recommendations (P < 0.0001) and referrals for instrumental assessment (P < 0.0001).
Despite differences in clinical management between groups, the end goal of reducing pneumonia in post stroke dysphagia was not achieved.
与吞咽困难相关的中风后肺炎会引发严重的健康问题并产生服务提供成本。已知隐性误吸会增加该人群的肺炎发生率和死亡率。本随机对照试验的主题是咳嗽反射测试(CRT)在降低急性中风患者肺炎发生率方面的效用。
被转诊进行吞咽评估的患者(N = 311)被分为两组:1)接受标准评估的对照组;2)接受标准评估并进行CRT的试验组。试验组的参与者接受雾化柠檬酸治疗,测试结果用于临床决策。两组的结局指标通过评估后3个月的肺炎发生率以及吞咽管理的其他临床指标来衡量。
数据分析表明,两组在肺炎发生率(P = 0.38)或死亡率(P = 0.15)方面无显著差异。CRT结果显示会影响饮食建议(P < 0.0001)和仪器评估转诊(P < 0.0001)。
尽管两组在临床管理上存在差异,但降低中风后吞咽困难患者肺炎发生率的最终目标并未实现。