Pretorius Etheresia, Lipinski Boguslaw, Bester Janette, Vermeulen Natasha, Soma Prashilla
Department of Physiology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Ultrastruct Pathol. 2013 Aug;37(4):254-7. doi: 10.3109/01913123.2013.778929. Epub 2013 May 14.
Serum albumin is an essential plasma protein that serves an important function in maintaining osmotic pressure. Low levels of this protein are associated with the kidney failure and hemodialysis that are often seen in diabetic patients who are at high risk of thrombotic events. In diabetes, fibrin fiber nets are changed to form dense matted deposits (DMDs, or parafibrin). Here the authors investigate whether parafibrin is also present in diagnosed low-albumin diabetes patients and whether the addition of human albumin to plasma from low-albumin diabetes type 2 individuals may change the architecture of the fibrin nets. The authors show that the addition of albumin to plasma of low-albumin diabetes patients progressively caused the DMDs typically found in these patients to revert back to ultrastructure typically seen in healthy individuals. This disease has an extremely complicated pathophysiology and thus cannot be considered as a simple condition. This study shows that serum albumin levels may play an important role in the structure of fibrin fibrils, making them more susceptible to the fibrinolytic degradation and elimination from the circulation.
血清白蛋白是一种重要的血浆蛋白，在维持渗透压方面发挥着重要作用。这种蛋白质水平低与肾衰竭和血液透析有关，而这在有血栓形成事件高风险的糖尿病患者中经常出现。在糖尿病中，纤维蛋白纤维网会发生变化，形成致密的缠结沉积物（DMDs，即副纤维蛋白）。在此，作者研究了副纤维蛋白是否也存在于已确诊的低白蛋白糖尿病患者中，以及向2型低白蛋白糖尿病个体的血浆中添加人白蛋白是否会改变纤维蛋白网的结构。作者表明，向低白蛋白糖尿病患者的血浆中添加白蛋白会逐渐使这些患者中常见的DMDs恢复为健康个体中通常可见的超微结构。这种疾病具有极其复杂的病理生理学，因此不能被视为一种简单的病症。这项研究表明，血清白蛋白水平可能在纤维蛋白原纤维的结构中起重要作用，使其更容易受到纤维蛋白溶解降解并从循环中清除。
