催化剂控制的 2-氨基苯并咪唑的化学选择性芳基化反应。
Catalyst-controlled chemoselective arylation of 2-aminobenzimidazoles.
机构信息
Department of Chemistry, Room 18-490, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
出版信息
Angew Chem Int Ed Engl. 2012 Oct 8;51(41):10364-7. doi: 10.1002/anie.201204710. Epub 2012 Sep 11.
Abstract
The chemoselective and complementary Pd-and Cu-catalyzed N-arylation of 2-aminobenzimidazoles is described. Selective N-arylation of the amino-group was achieved with a Pd-catalyzed method, while selective N-arylation of azole nitrogen was achieved with a Cu-catalyzed procedure. The utility of these complementary sets of conditions is demonstrated in several two-step, selective syntheses of di-arylated aminoazoles.
摘要
本文描述了 2-氨基苯并咪唑的钯和铜催化的化学选择性和互补的 N-芳基化反应。通过钯催化的方法实现了氨基的选择性 N-芳基化，而通过铜催化的方法实现了唑氮的选择性 N-芳基化。这些互补条件的实用性在几种两步、选择性合成二芳基化氨基唑的反应中得到了证明。
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