Kullmann Stephanie, Giel Katrin E, Hu Xiaochen, Bischoff Stephan C, Teufel Martin, Thiel Ansgar, Zipfel Stephan, Preissl Hubert
fMEG Center, University of Tübingen, 72076 Tübingen, Germany, Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, 72076 Tübingen, Germany, German Center for Diabetes Research, 85764 Neuherberg, Germany, Department of Psychosomatic Medicine and Psychotherapy, Medical University Hospital Tübingen, 72076 Tübingen, Germany, Department of Psychiatry, University of Bonn, 53105 Bonn, Germany, Institute of Nutritional Medicine, University Hohenheim, 70599 Stuttgart, Germany, and Institute of Sport Science, University Tübingen, 72076 Tübingen, GermanyfMEG Center, University of Tübingen, 72076 Tübingen, Germany, Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, 72076 Tübingen, Germany, German Center for Diabetes Research, 85764 Neuherberg, Germany, Department of Psychosomatic Medicine and Psychotherapy, Medical University Hospital Tübingen, 72076 Tübingen, Germany, Department of Psychiatry, University of Bonn, 53105 Bonn, Germany, Institute of Nutritional Medicine, University Hohenheim, 70599 Stuttgart, Germany, and Institute of Sport Science, University Tübingen, 72076 Tübingen, GermanyfMEG Center, University of Tübingen, 72076 Tübingen, Germany, Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, 72076 Tübingen, Germany, German Center for Diabetes Research, 85764 Neuherberg, Germany, Department of Psychosomatic Medicine and Psychotherapy, Medical University Hospital Tübingen, 72076 Tübingen, Germany, Department of Psychiatry, University of Bonn, 53105 Bonn, Germany, Institute of Nutritional Medicine, University Hohenheim, 70599 Stuttgart, Germany, and Institute of Sport Science, University Tübingen, 72076 Tübingen, Germany
fMEG Center, University of Tübingen, 72076 Tübingen, Germany, Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, 72076 Tübingen, Germany, German Center for Diabetes Research, 85764 Neuherberg, Germany, Department of Psychosomatic Medicine and Psychotherapy, Medical University Hospital Tübingen, 72076 Tübingen, Germany, Department of Psychiatry, University of Bonn, 53105 Bonn, Germany, Institute of Nutritional Medicine, University Hohenheim, 70599 Stuttgart, Germany, and Institute of Sport Science, University Tübingen, 72076 Tübingen, Germany.
Soc Cogn Affect Neurosci. 2014 Jul;9(7):917-23. doi: 10.1093/scan/nst070. Epub 2013 May 14.
Besides food restriction, hyperactivity is considered a key behavioral trait of anorexia nervosa (AN), playing a major role in the pathogenesis and progression of the disorder. However, the underlying neurophysiology remains poorly understood. We used functional magnetic resonance imaging during two affective go/no-go tasks to probe inhibitory control in response to stimuli depicting physical activity vs inactivity and food vs non-food in AN patients compared with 26 healthy athlete and non-athlete controls. We hypothesized that neural correlates of behavioral inhibition are biased by the emotional information of the stimuli in AN patients, leading to a differential neural inhibitory pattern during the two tasks. Indeed, we found reduced response inhibition for food and non-food images in the putamen, while stimuli depicting physical activity resulted in an exaggerated response of the prefrontal cortex (PFC) and cerebellum in AN patients. However, both AN patients and athletes revealed an increased response in the somatosensory cortex to physical activity stimuli. These results suggest that physical activity stimuli might place an increased demand on the inhibitory control system in AN patients. The resulting hyperactivity of the PFC and cerebellum may lead to altered executive function and motor control, sustaining increased physical activity in AN patients.
除食物限制外，多动被认为是神经性厌食症（AN）的一个关键行为特征，在该疾病的发病机制和进展中起主要作用。然而，其潜在的神经生理学仍知之甚少。我们在两项情感性停止信号任务中使用功能磁共振成像，以探究与26名健康运动员和非运动员对照相比，AN患者对描绘身体活动与不活动以及食物与非食物的刺激做出反应时的抑制控制情况。我们假设，行为抑制的神经关联在AN患者中受到刺激的情感信息的影响，导致在两项任务中出现不同的神经抑制模式。事实上，我们发现壳核中对食物和非食物图像的反应抑制减弱，而描绘身体活动的刺激在AN患者中导致前额叶皮质（PFC）和小脑的反应过度。然而，AN患者和运动员在体感皮质对身体活动刺激的反应均增强。这些结果表明，身体活动刺激可能对AN患者的抑制控制系统提出了更高的要求。PFC和小脑由此产生的多动可能导致执行功能和运动控制改变，使AN患者的身体活动持续增加。
