Department of Neuroscience, Uppsala University, Uppsala, Sweden.
PLoS One. 2011;6(7):e22259. doi: 10.1371/journal.pone.0022259. Epub 2011 Jul 20.
Previous fMRI studies show that women with eating disorders (ED) have differential neural activation to viewing food images. However, despite clinical differences in their responses to food, differential neural activation to thinking about eating food, between women with anorexia nervosa (AN) and bulimia nervosa (BN) is not known.
We compare 50 women (8 with BN, 18 with AN and 24 age-matched healthy controls [HC]) while they view food images during functional Magnetic Resonance Imaging (fMRI).
In response to food (vs non-food) images, women with BN showed greater neural activation in the visual cortex, right dorsolateral prefrontal cortex, right insular cortex and precentral gyrus, women with AN showed greater activation in the right dorsolateral prefrontal cortex, cerebellum and right precuneus. HC women activated the cerebellum, right insular cortex, right medial temporal lobe and left caudate. Direct comparisons revealed that compared to HC, the BN group showed relative deactivation in the bilateral superior temporal gyrus/insula, and visual cortex, and compared to AN had relative deactivation in the parietal lobe and dorsal posterior cingulate cortex, but greater activation in the caudate, superior temporal gyrus, right insula and supplementary motor area.
Women with AN and BN activate top-down cognitive control in response to food images, yet women with BN have increased activation in reward and somatosensory regions, which might impinge on cognitive control over food consumption and binge eating.
先前的 fMRI 研究表明，患有饮食失调症（ED）的女性在观看食物图像时会出现不同的神经激活。然而，尽管在对食物的反应上存在临床差异，但厌食症（AN）和贪食症（BN）女性在思考进食时的神经激活是否存在差异尚不清楚。
我们比较了 50 名女性（8 名 BN，18 名 AN 和 24 名年龄匹配的健康对照组 [HC]）在功能磁共振成像（fMRI）期间观看食物图像时的情况。
与非食物图像相比，BN 组女性在视觉皮层、右侧背外侧前额叶皮层、右侧脑岛和中央前回的神经激活更大，AN 组女性在右侧背外侧前额叶皮层、小脑和右侧楔前叶的神经激活更大。HC 女性激活了小脑、右侧脑岛、右侧内侧颞叶和左侧尾状核。直接比较显示，与 HC 相比，BN 组双侧颞上回/脑岛和视觉皮层的相对去激活，与 AN 相比，顶叶和后扣带回背侧的相对去激活，而尾状核、颞上回、右侧脑岛和补充运动区的激活增加。
患有 AN 和 BN 的女性在观看食物图像时会激活自上而下的认知控制，但 BN 女性在奖励和躯体感觉区域的激活增加，这可能会影响对食物摄入和暴食的认知控制。
