Ward J P
Br J Urol. 1975 Feb;47(1):17-24. doi: 10.1111/j.1464-410x.1975.tb03913.x.
To determine the optimum temperature at which the in situ kidney should be maintained while it is ischaemic, 47 mongrel dogs were studied. 35 of these underwent 90 minutes of left renal ischaemia with the kidney temperature maintained at 37 degree, 30 degree, 22 degree, 15 degree and 0 degree C respectively. The effect on renal function was determined by measurements of G.F.R. before and at regular 15-minute intervals after the inschaemic period. Computer statistical analysis exposed the optimum temperature to be 15 degree C. Renal artery blood flow, renal histology, 15-Cr labelled platelets and renal arteriography were used to determine the mechanism of ischaemic injury. Quantitation of renal cell injury confirmed that no additional protection to ischaemia could be gained by colling below 15 degree C. 15 degree C is recommended as the optimum temperature for use in clinical renal hypothermia.
为了确定原位肾脏在缺血时应维持的最佳温度，对47只杂种狗进行了研究。其中35只狗经历了90分钟的左肾缺血，肾脏温度分别维持在37℃、30℃、22℃、15℃和0℃。通过在缺血期之前和之后每隔15分钟定期测量肾小球滤过率（G.F.R.）来确定对肾功能的影响。计算机统计分析表明最佳温度为15℃。使用肾动脉血流量、肾脏组织学、15-Cr标记血小板和肾动脉造影来确定缺血性损伤的机制。肾细胞损伤的定量分析证实，将温度降至15℃以下并不能获得对缺血的额外保护。建议将15℃作为临床肾低温治疗的最佳温度。
