Ahmad Jamal, Rafat Dalia
Centre for Diabetes and Endocrinology, Faculty of Medicine, JN Medical College, Aligarh Muslim University, Aligarh 202002, India.
Diabetes Metab Syndr. 2013 Apr-Jun;7(2):118-22. doi: 10.1016/j.dsx.2013.02.004. Epub 2013 Mar 15.
Conditions that affect erythrocyte turnover influence HbA1c concentrations and the International Expert Committee has warned clinicians to be aware of any conditions that could affect the turnover of red blood cells. Although many forms of anemia are associated with lowering of HbA1c, iron deficiency has been shown to shift HbA1c slightly upward. The exact mechanism through which iron deficiency anemia affects HbA1c levels, however still remains unclear. The explanations provided above are merely speculations, warranting further studies to confirm and elucidate the role of these factors. As little work has been done in this field so future and large scale studies are required which may address HbA1c enhancing effect and the mechanism of increased HbA glycation in iron deficiency properly.
影响红细胞更新的状况会影响糖化血红蛋白（HbA1c）浓度，国际专家委员会已警告临床医生要注意任何可能影响红细胞更新的状况。尽管多种贫血形式都与HbA1c降低有关，但缺铁已被证明会使HbA1c略有上升。然而，缺铁性贫血影响HbA1c水平的确切机制仍不清楚。上述解释仅仅是推测，需要进一步研究来证实和阐明这些因素的作用。由于该领域的研究较少，因此需要未来进行大规模研究，以恰当探讨缺铁时HbA1c的升高作用及血红蛋白A糖化增加的机制。
