四种β-肾上腺素能受体拮抗剂在哮喘患者中的比较。
A comparison of four beta-adrenoceptor antagonists in patients with asthma.
作者信息
Benson M K, Berrill W T, Cruickshank J M, Sterling G S
出版信息
Br J Clin Pharmacol. 1978 May;5(5):415-9. doi: 10.1111/j.1365-2125.1978.tb01647.x.
Abstract
1 Cardiovascular and airways response to two non-cardioselective beta-adrenoceptor blocking drugs, propranolol and pindolol (with partial agonist activity) and two cardioselective beta-adrenoceptor blocking drugs, acebutolol (with partial agonist activity) and atenolol, were compared in twelve patients with asthma. 2 All four drugs produced a significant reduction in resting pulse rate and prevented the increase in heart rate following inhaled isoprenaline (1,500 microgram). 3 Seven patients in clinical remission showed no significant bronchoconstrictor response to any of the drugs. In the remaining five patients, bronchoconstriction was greatest following propranolol (mean reduction in FEV1 26.6%) and least following atenolol (mean reduction in FEV1 6.5%). 4 The bronchodilator response to inhaled isoprenaline was blocked by propranolol and pindolol but not by acebutolol and atenolol. 5 Partial agonist activity did not appear to be clinically useful.
摘要
- 在12名哮喘患者中比较了两种非心脏选择性β-肾上腺素受体阻滞剂普萘洛尔和吲哚洛尔（具有部分激动剂活性）以及两种心脏选择性β-肾上腺素受体阻滞剂醋丁洛尔（具有部分激动剂活性）和阿替洛尔对心血管和气道的反应。2. 所有四种药物均使静息心率显著降低，并防止吸入异丙肾上腺素（1500微克）后心率增加。3. 7名临床缓解的患者对任何一种药物均未表现出明显的支气管收缩反应。在其余5名患者中，普萘洛尔后的支气管收缩最明显（第一秒用力呼气量平均降低26.6%），阿替洛尔后的支气管收缩最不明显（第一秒用力呼气量平均降低6.5%）。4. 吸入异丙肾上腺素后的支气管扩张反应被普萘洛尔和吲哚洛尔阻断，但未被醋丁洛尔和阿替洛尔阻断。5. 部分激动剂活性在临床上似乎并无用处。
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Bronchial response to beta-adrenergic blockade.支气管对β-肾上腺素能阻滞剂的反应。
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