Institute of Sports Medicine, Department of Orthopaedic Surgery M, Bispebjerg Hospital, and Centre for Healthy Ageing, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
J Appl Physiol (1985). 2013 Sep;115(6):900-8. doi: 10.1152/japplphysiol.00044.2013. Epub 2013 May 16.
Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely consumed by athletes worldwide, despite growing evidence for a negative influence on the adaptation of skeletal muscle to exercise, at least in young healthy individuals. This review focuses on the potential of NSAIDs to alter the activity of satellite cells, the muscle stem cell responsible for repair and maintenance of skeletal muscle. The signaling pathways that are potentially modified by NSAID exposure are also considered. Growth factors as well as inflammatory cells and connective tissue appear to be key factors in the response of muscle under conditions where cyclooxygenase and prostaglandin activity are blocked through NSAID ingestion or infusion. Discrepancies in the literature regarding the response of young and old individuals are addressed, where it appears that the elderly may benefit from NSAID ingestion, although this clearly requires further study. The long-term implications for the muscle of the apparent inhibitory effect of NSAIDs on satellite cells in younger individuals are not clear, and it is possible these may first become apparent with chronic use in athletes training at a high level or with advancing age. Reports of the potential for NSAIDs to alter prostaglandin and growth factor signaling provide a basis for further study of the mechanism of NSAID action on satellite cells.
非甾体抗炎药（NSAIDs）在全球范围内被运动员广泛使用，尽管越来越多的证据表明它们对骨骼肌肉适应运动的能力产生负面影响，至少在年轻健康个体中是如此。本综述重点讨论了 NSAIDs 改变卫星细胞活性的潜力，卫星细胞是负责修复和维持骨骼肌的肌肉干细胞。还考虑了 NSAID 暴露可能改变的信号通路。生长因子以及炎症细胞和结缔组织似乎是肌肉在环氧化酶和前列腺素活性被 NSAID 摄入或输注阻断的情况下做出反应的关键因素。关于年轻人和老年人对 NSAID 反应的文献存在差异，老年人似乎从 NSAID 摄入中受益，尽管这显然需要进一步研究。长期来看，在年轻个体中 NSAIDs 对卫星细胞的明显抑制作用对肌肉的影响尚不清楚，而且随着高水平训练的运动员或随着年龄的增长而长期使用，这些影响可能首先变得明显。关于 NSAIDs 改变前列腺素和生长因子信号的可能性的报告为进一步研究 NSAID 对卫星细胞作用的机制提供了依据。
