Model Animal Research Center of Nanjing University and MOE Key Laboratory of Model Animals for Disease Study, 12 Xuefu Road, Pukou High-Tech Zone, Nanjing 210061, China.
Biochem Biophys Res Commun. 2013 Jun 14;435(4):597-602. doi: 10.1016/j.bbrc.2013.05.025. Epub 2013 May 16.
Resveratrol (RSV) is a natural compound found in grapes and red wine. It has been well known for its beneficial effects as a dietary supplement in prevention of cardiovascular diseases and cancer. Recently, in vitro studies have reported the neuroprotective role of RSV in neurodegenerative process in Alzheimer's disease (AD). However, in vivo effects of RSV on the decline of brain function accompanying the aging process, especially those on cognitive loss, have not been not investigated. Here we report that, after intraventricular injection of RSV for one week in 8-9 month-old mice, the long-term memory formation and the LTP induction from hippocampus CA1 were improved. The RSV enhancement effects were blocked in SIRT1 mutant mice. Additional experiments suggest that RSV effects are likely to be mediated through reduced expressions of miR-134 and miR-124, which may in turn up-regulate CREB levels to subsequently promote BDNF synthesis. These findings demonstrate a role for RSV in cognition and a microRNA-CREB-BDNF mechanism by which RSV regulates these processes, demonstrating its value as a potential therapeutic target against CNS disorders in aging.
白藜芦醇（RSV）是一种天然存在于葡萄和红酒中的化合物。它作为一种膳食补充剂，在预防心血管疾病和癌症方面的有益作用已广为人知。最近，体外研究报告称 RSV 在阿尔茨海默病（AD）的神经退行性过程中具有神经保护作用。然而，RSV 对衰老过程中伴随的大脑功能下降（特别是认知能力下降）的体内影响尚未得到研究。在这里，我们报告称，在 8-9 个月大的小鼠的侧脑室注射 RSV 一周后，其长期记忆形成和海马 CA1 的 LTP 诱导得到改善。在 SIRT1 突变小鼠中，RSV 的增强作用被阻断。此外的实验表明，RSV 的作用可能是通过降低 miR-134 和 miR-124 的表达来介导的，这可能反过来上调 CREB 水平，从而促进 BDNF 的合成。这些发现表明 RSV 在认知中的作用，以及 RSV 调节这些过程的 microRNA-CREB-BDNF 机制，证明其作为治疗衰老相关中枢神经系统疾病的潜在治疗靶点的价值。
