重复视觉刺激可促进重度弱视的恢复。
Repetitive visual stimulation enhances recovery from severe amblyopia.
机构信息
Department of Biology, University of Maryland, College Park, Maryland 20742, USA.
出版信息
Learn Mem. 2013 May 16;20(6):311-7. doi: 10.1101/lm.030361.113.
Abstract
Severe amblyopia, characterized by a significant reduction in visual acuity through the affected eye, is highly resistant to reversal in adulthood. We have previously shown that synaptic plasticity can be reactivated in the adult rat visual cortex by dark exposure, and the reactivated plasticity can be harnessed to promote the recovery from severe amblyopia. Here we show that deprived-eye visually evoked responses are rapidly strengthened in dark-exposed amblyopes by passive viewing of repetitive visual stimuli. Surprisingly, passive visual stimulation rapidly enhanced visually evoked responses to novel stimuli and enhanced the recovery from severe amblyopia driven by performance of active visual discriminations. Thus a series of simple, noninvasive manipulations of visual experience can be used in combination to significantly guide the recovery of visual response strength, selectivity, and spatial acuity in adult amblyopes.
摘要
重度弱视的特征是受影响眼的视力明显下降，在成年后很难逆转。我们之前已经表明，在成年大鼠视觉皮层中，通过暗适应可以重新激活突触可塑性，并且可以利用重新激活的可塑性来促进重度弱视的恢复。在这里，我们表明通过被动观看重复的视觉刺激，在暗适应弱视者中，剥夺眼的视觉诱发反应可以迅速增强。令人惊讶的是，被动视觉刺激可以迅速增强对新刺激的视觉反应，并增强由主动视觉辨别驱动的重度弱视的恢复。因此，可以将一系列简单的、非侵入性的视觉经验操作组合使用，以显著引导成年弱视者的视觉反应强度、选择性和空间锐度的恢复。
相似文献
1
Repetitive visual stimulation enhances recovery from severe amblyopia.
Learn Mem. 2013 May 16;20(6):311-7. doi: 10.1101/lm.030361.113.
2
tDCS recovers depth perception in adult amblyopic rats and reorganizes visual cortex activity.
Behav Brain Res. 2019 Sep 16;370:111941. doi: 10.1016/j.bbr.2019.111941. Epub 2019 May 9.
3
Recovery from chronic monocular deprivation following reactivation of thalamocortical plasticity by dark exposure.
Nat Commun. 2011;2:317. doi: 10.1038/ncomms1312.
4
Experience-dependent recovery of vision following chronic deprivation amblyopia.
Nat Neurosci. 2007 Sep;10(9):1134-6. doi: 10.1038/nn1965. Epub 2007 Aug 12.
5
Optimization of visual training for full recovery from severe amblyopia in adults.
Learn Mem. 2016 Jan 19;23(2):99-103. doi: 10.1101/lm.040295.115. Print 2016 Feb.
6
[Impact of alternative eye photostimulation technique on visually evoked potentials in children with amblyopia].
Vestn Oftalmol. 2007 Jul-Aug;123(4):29-32.
7
Intrinsic, light-independent and visual activity-dependent mechanisms cooperate in the shaping of the field response in rat visual cortex.
J Neurosci. 2007 Aug 1;27(31):8422-9. doi: 10.1523/JNEUROSCI.1180-07.2007.
8
Experience-dependent reactivation of ocular dominance plasticity in the adult visual cortex.
Exp Neurol. 2010 Nov;226(1):100-9. doi: 10.1016/j.expneurol.2010.08.009. Epub 2010 Aug 14.
9
Enduring critical period plasticity visualized by transcranial flavoprotein imaging in mouse primary visual cortex.
J Neurosci. 2006 Nov 8;26(45):11775-85. doi: 10.1523/JNEUROSCI.1643-06.2006.
10
A rich environmental experience reactivates visual cortex plasticity in aged rats.
Exp Gerontol. 2012 Apr;47(4):337-41. doi: 10.1016/j.exger.2012.01.007. Epub 2012 Feb 4.
引用本文的文献
1
Repeated passive visual experience modulates spontaneous and non-familiar stimuli-evoked neural activity.
Sci Rep. 2023 Nov 27;13(1):20907. doi: 10.1038/s41598-023-47957-1.
2
Psychedelics and Neural Plasticity: Therapeutic Implications.
J Neurosci. 2022 Nov 9;42(45):8439-8449. doi: 10.1523/JNEUROSCI.1121-22.2022.
3
Chronic Monocular Deprivation Reveals MMP9-Dependent and -Independent Aspects of Murine Visual System Plasticity.
Int J Mol Sci. 2022 Feb 23;23(5):2438. doi: 10.3390/ijms23052438.
4
High-Frequency Visual Stimulation Primes Gamma Oscillations for Visually Evoked Phase Reset and Enhances Spatial Acuity.
Cereb Cortex Commun. 2021 Mar 3;2(2):tgab016. doi: 10.1093/texcom/tgab016. eCollection 2021.
5
The Potential of Virtual Reality for Inducing Neuroplasticity in Children with Amblyopia.
J Ophthalmol. 2020 Jun 29;2020:7067846. doi: 10.1155/2020/7067846. eCollection 2020.
6
Homeostatic regulation of perisynaptic matrix metalloproteinase 9 (MMP9) activity in the amblyopic visual cortex.
Elife. 2019 Dec 23;8:e52503. doi: 10.7554/eLife.52503.
7
17α Estradiol promotes plasticity of spared inputs in the adult amblyopic visual cortex.
Sci Rep. 2019 Dec 13;9(1):19040. doi: 10.1038/s41598-019-55158-y.
8
Contrast and spatial frequency modulation for diagnosis of amblyopia: An electrophysiological approach.
J Curr Ophthalmol. 2018 Nov 1;31(1):72-79. doi: 10.1016/j.joco.2018.09.010. eCollection 2019 Mar.
9
Enhanced Plasticity of Human Evoked Potentials by Visual Noise During the Intervention of Steady-State Stimulation Based Brain-Computer Interface.
Front Neurorobot. 2018 Nov 29;12:82. doi: 10.3389/fnbot.2018.00082. eCollection 2018.
10
Critical periods in amblyopia.
Vis Neurosci. 2018 Jan;35:E014. doi: 10.1017/S0952523817000219.
本文引用的文献
1
Darkness alters maturation of visual cortex and promotes fast recovery from monocular deprivation.
Curr Biol. 2013 Mar 4;23(5):382-6. doi: 10.1016/j.cub.2013.01.017. Epub 2013 Feb 14.
2
Dark exposure extends the integration window for spike-timing-dependent plasticity.
J Neurosci. 2012 Oct 24;32(43):15027-35. doi: 10.1523/JNEUROSCI.2545-12.2012.
3
The BCM theory of synapse modification at 30: interaction of theory with experiment.
Nat Rev Neurosci. 2012 Nov;13(11):798-810. doi: 10.1038/nrn3353.
4
Video-game play induces plasticity in the visual system of adults with amblyopia.
PLoS Biol. 2011 Aug;9(8):e1001135. doi: 10.1371/journal.pbio.1001135. Epub 2011 Aug 30.
5
NR2B-subunit dependent facilitation of long-term potentiation in primary visual cortex following visual discrimination training of adult rats.
Eur J Neurosci. 2011 Oct;34(8):1222-9. doi: 10.1111/j.1460-9568.2011.07842.x. Epub 2011 Sep 6.
6
Recovery from chronic monocular deprivation following reactivation of thalamocortical plasticity by dark exposure.
Nat Commun. 2011;2:317. doi: 10.1038/ncomms1312.
7
Improvement and impairment of visually guided behavior through LTP- and LTD-like exposure-based visual learning.
Curr Biol. 2011 May 24;21(10):876-82. doi: 10.1016/j.cub.2011.03.065. Epub 2011 May 5.
8
A refractory period for rejuvenating GABAergic synaptic transmission and ocular dominance plasticity with dark exposure.
J Neurosci. 2010 Dec 8;30(49):16636-42. doi: 10.1523/JNEUROSCI.4384-10.2010.
9
Visual experience induces long-term potentiation in the primary visual cortex.
J Neurosci. 2010 Dec 1;30(48):16304-13. doi: 10.1523/JNEUROSCI.4333-10.2010.
10
Visual perceptual learning induces long-term potentiation in the visual cortex.
Neuroscience. 2011 Jan 13;172:219-25. doi: 10.1016/j.neuroscience.2010.10.078. Epub 2010 Nov 4.
Zotero 插件