Dept of Medicine, Helsingborg Hospital, Sweden.
Med Hypotheses. 2013 Aug;81(2):338-42. doi: 10.1016/j.mehy.2013.03.046. Epub 2013 May 17.
The incidence of type 1 diabetes among children has almost doubled during the last decades in Sweden. Type 1 diabetes is considered as an autoimmune disease with unknown aetiology. Here we propose that the immune reaction may be initiated by food-derived mechanisms. The incidence of diabetes parallels an increased consumption of pasta, white bread, meat, cheese, low-fat milk, exotic fruits, soda, and snacks. Simultaneously, the consumption of potatoes, butter, high-fat milk, and domestic fruit has decreased. Three categories of food related reaction mechanisms are discussed against the following items (1) proteins from wheat, meat, and milk, (2) fat from processed food, and (3) exotic fruits. The current food consumption is suggested to initiate a pro-inflammatory reaction in the intestine and thereby reduce the intestinal barrier function. This may influence tolerance development and thus pave the way for an autoimmune attack on pancreatic beta cells.
在过去几十年中，瑞典儿童 1 型糖尿病的发病率几乎翻了一番。1 型糖尿病被认为是一种病因不明的自身免疫性疾病。在这里，我们提出免疫反应可能是由食物来源的机制引发的。糖尿病的发病率与意大利面、白面包、肉、奶酪、低脂牛奶、异国水果、苏打水和零食的消费增加呈平行关系。与此同时，土豆、黄油、高脂肪牛奶和国产水果的消费减少了。讨论了三种与以下项目相关的食物相关反应机制：（1）来自小麦、肉和牛奶的蛋白质，（2）加工食品中的脂肪，以及（3）异国水果。目前的食物消费被认为会在肠道中引发炎症反应，从而降低肠道屏障功能。这可能会影响耐受性的发展，从而为针对胰腺β细胞的自身免疫攻击铺平道路。
