Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan.
PLoS One. 2012;7(8):e42474. doi: 10.1371/journal.pone.0042474. Epub 2012 Aug 3.
Previous animal studies have shown that perfluorinated compounds (PFCs) have adverse impacts on birth outcomes, but the results have been inconclusive in humans. We investigated associations between prenatal exposure to perfluorooctanoic acid (PFOA), perfluorooctyl sulfonate (PFOS), perfluorononanoic acid (PFNA), and perfluoroundecanoic acid (PFUA) and birth outcomes.
In total, 429 mother-infant pairs were recruited from the Taiwan Birth Panel Study (TBPS). Demographic data were obtained by interviewing mothers using a structured questionnaire and birth outcomes were extracted from medical records. Cord blood was collected for PFOA, PFOS, PFNA, and PFUA analysis by ultra-high-performance liquid chromatography/tandem mass spectrometry.
The geometric mean (standard deviation) levels of PFOA, PFOS, PFNA, and PFUA in cord blood plasma were 1.84 (2.23), 5.94 (1.95), 2.36(4.74), and 10.26 (3.07) ng/mL, respectively. Only PFOS levels were found to be inversely associated with gestational age, birth weight, and head circumference [per ln unit: adjusted β (95% confidence interval, CI) = -0.37 (-0.60, -0.13) wks, -110.2 (-176.0, -44.5) gm and -0.25 (-0.46, -0.05) cm]. Additionally, the odds ratio of preterm birth, low birth weight, and small for gestational age increased with PFOS exposure [per ln unit: adjusted odds ratio (OR) (95%CI) = 2.45 (1.47, 4.08), 2.61(0.85, 8.03) and 2.27 (1.25, 4.15)]. When PFOS levels were divided into quartiles, a dose-response relation was observed. However, PFOA, PFNA, and PFUA were not observed to have any convincing impact on birth outcomes.
An adverse dose-dependent association was observed between prenatal PFOS exposure and birth outcomes. However, no associations were found for the other examined PFCs.
先前的动物研究表明，全氟化合物（PFCs）对出生结局有不良影响，但在人类中的结果尚无定论。我们研究了产前暴露于全氟辛酸（PFOA）、全氟辛烷磺酸（PFOS）、全氟壬酸（PFNA）和全氟癸酸（PFDA）与出生结局之间的关系。
总共从台湾出生队列研究（TBPS）中招募了 429 对母婴。通过使用结构化问卷对母亲进行访谈获得人口统计学数据，从病历中提取出生结局。通过超高效液相色谱/串联质谱法在脐血血浆中分析 PFOA、PFOS、PFNA 和 PFDA。
脐血血浆中 PFOA、PFOS、PFNA 和 PFDA 的几何均数（标准差）水平分别为 1.84（2.23）、5.94（1.95）、2.36（4.74）和 10.26（3.07）ng/ml。仅发现 PFOS 水平与胎龄、出生体重和头围呈负相关[每单位 ln：调整β（95%置信区间，CI）=-0.37（-0.60，-0.13）周，-110.2（-176.0，-44.5）克和-0.25（-0.46，-0.05）cm]。此外，PFOS 暴露与早产、低出生体重和小于胎龄儿的比值比增加[每单位 ln：调整比值比（OR）（95%CI）=2.45（1.47，4.08）、2.61（0.85，8.03）和 2.27（1.25，4.15）]。当将 PFOS 水平分为四等分时，观察到剂量反应关系。然而，没有发现 PFOA、PFNA 和 PFDA 对出生结局有任何明显影响。
产前 PFOS 暴露与出生结局呈不良剂量依赖性关联。然而，对于其他检查的 PFCs，没有发现关联。
