Ghaffari Javad, Ebrahimi Mahbobeh, Makhlough Atieh, Mohammadjafari Hamid, Nazari Zeinab
Department of Immunology, Mazandaran University of Medical Sciences, Sari, Iran.
Iran J Kidney Dis. 2013 May;7(3):187-90.
Human T-cell lymphotropic virus 1 (HTLV1) is a lymphotropic virus which can be transmitted through unprotected sexual activity, breast feeding, and blood transfusion. Although most of HTLV1-infected individuals remain asymptomatic carriers, 1% to 5% and 3% to 5% develop adult T-cell leukemia and HTLV1-associated myelopathy/tropical spastic paraparesis, respectively. The aim of this study was to determine the prevalence of HTLV1 infection in hemodialysis patients in Sari and Ghaemshahr. This cross-sectional study was conducted on160 patients using random samples selection, and included 80 men and 80 women (mean age, 59.1 ± 14.7 years). All the samples were screened for HTLV1 antibody by enzyme-linked immunosorbent assay and positive samples were confirmed by Western blot assay. Only 1 patient had a positive anti-HTLV1 enzyme-linked immunosorbent assay test, which was confirmed by Western blot. The overall prevalence of HTLV1 seropositivity was 0.6%. The patient was a 21-year-old woman with a history of multiple blood transfusions. She had a history of unsuccessful kidney transplantation and had been on hemodialysis before transplant, too. This study suggests that HTLV1 infection may not be prevalent in high-risk patients in Mazandaran province, and there is no need for HTLV1 screening of blood samples.
人类嗜T细胞病毒1型（HTLV1）是一种嗜淋巴细胞病毒，可通过无保护的性行为、母乳喂养和输血传播。虽然大多数感染HTLV1的个体仍为无症状携带者，但分别有1%至5%和3%至5%的人会发展为成人T细胞白血病和HTLV1相关脊髓病/热带痉挛性截瘫。本研究的目的是确定萨里和加姆沙赫尔血液透析患者中HTLV1感染的患病率。这项横断面研究采用随机抽样方法对160名患者进行，其中包括80名男性和80名女性（平均年龄59.1 ± 14.7岁）。所有样本均通过酶联免疫吸附测定法筛查HTLV1抗体，阳性样本通过蛋白质印迹法确认。只有1名患者酶联免疫吸附测定法检测抗HTLV1呈阳性，并经蛋白质印迹法确认。HTLV1血清阳性的总体患病率为0.6%。该患者为一名21岁女性，有多次输血史。她有肾移植失败史，移植前也接受过血液透析。本研究表明，马赞德兰省高危患者中HTLV1感染可能并不普遍，无需对血样进行HTLV1筛查。
