Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei 11031, Taiwan.
Evid Based Complement Alternat Med. 2013;2013:408734. doi: 10.1155/2013/408734. Epub 2013 Apr 16.
Benign prostatic hyperplasia (BPH), an imbalance between androgen/estrogen, overexpression of stromal, and epithelial growth factors associated with chronic inflammation, has become an atypical direct cause of mortality of aged male diseases. Ginkgo possesses anti-inflammatory, blood flow-enhancing, and free radical scavenging effects. Considering strenuous exercise can reduce BPH risks, we hypothesize Ginkgo + exercise (Ginkgo + Ex) could be beneficial to BPH. To verify this, rat BPH model was induced by s.c. 3.5 mg testosterone (T) and 0.1 mg estradiol (E2) per head per day successively for 8 weeks, using mineral oil as placebo. Cerenin(®) 8.33 μ L/100 g was applied s.c. from the 10th to the 13th week, and simultaneously, Ex was applied (30 m/min, 3 times/week). In BPH, Ginkgo alone had no effect on T, 5 α -reductase, and dihydrotestosterone (DHT), but suppressed androgen receptor (AR), aromatase, E2 and estrogen receptor (ER), and the proliferating cell nuclear antigen (PCNA); Ex alone significantly reduced T, aromatase, E2, ER, AR, and PCNA, but highly raised DHT. While Ginkgo + Ex androgenically downregulated T, aromatase, E2, and ER, but upregulated DHT, AR, and PCNA, implying Ginkgo + Ex tended to worsen BPH. Conclusively, Ginkgo or Ex alone may be more beneficial than Ginkgo + Ex for treatment of BPH.
良性前列腺增生（BPH）是一种雄激素/雌激素失衡、间质和上皮生长因子过度表达与慢性炎症相关的疾病，已成为老年男性疾病非典型的直接致死原因。银杏具有抗炎、增强血流和清除自由基的作用。考虑到剧烈运动可以降低 BPH 的风险，我们假设银杏+运动（Ginkgo + Ex）可能对 BPH 有益。为了验证这一点，我们使用皮下注射 3.5mg 睾酮（T）和 0.1mg 雌二醇（E2）每天每头，连续 8 周的方法诱导大鼠 BPH 模型，用矿物油作为安慰剂。从第 10 周到第 13 周，每天皮下注射 Cerenin(®)8.33μL/100g，并同时进行 Ex（30m/min，每周 3 次）。在 BPH 中，银杏单独使用对 T、5α-还原酶和二氢睾酮（DHT）没有影响，但抑制雄激素受体（AR）、芳香酶、E2 和雌激素受体（ER）和增殖细胞核抗原（PCNA）；Ex 单独使用可显著降低 T、芳香酶、E2、ER、AR 和 PCNA，但可显著升高 DHT。而银杏+Ex 则表现为雄激素下调 T、芳香酶、E2 和 ER，但上调 DHT、AR 和 PCNA，这意味着银杏+Ex 可能使 BPH 恶化。综上所述，银杏或 Ex 单独使用可能比银杏+Ex 更有利于治疗 BPH。
