School of Biological Sciences, Flinders University, GPO Box 2100, Adelaide, SA 5001, Australia.
Evid Based Complement Alternat Med. 2013;2013:837370. doi: 10.1155/2013/837370. Epub 2013 Apr 17.
Marine molluscs from the family Muricidae are under development as a potential medicinal food for the prevention of colon cancer and treatment of gynaecological cancers. Here we report the outcome of the first in vivo toxicity assessment on an anticancer extract from a muricid mollusc containing brominated indole derivatives. Mice received the concentrated lipophilic extract by daily oral gavage over a two-week period. Mortality or clinical toxicity symptoms resulting from the extract were not detected during the trial, and there was no difference in the body weight of treated and control mice at the end of the trial. Histological analysis revealed some evidence for mild, idiosyncratic effects on the gastrointestinal tract and liver, including necrosis, fatty change, and inflammation in a small proportion (<40%) of mice. This is likely to result from first-pass hepatic metabolism of tyrindoxyl sulphate combined with second-pass metabolism of indoles. Overall however, oral administration of muricid extract containing brominated indoles does not result in severe clinical toxicity.
海洋软体动物宝螺科正在被开发为一种预防结肠癌和妇科癌症的潜在药用食品。在这里，我们报告了首例海洋软体动物抗癌提取物的体内毒性评估结果，该提取物含有溴代吲哚衍生物。小鼠在两周的时间内通过每日口服灌胃接受浓缩亲脂性提取物。试验过程中未发现提取物引起的死亡或临床毒性症状，试验结束时，处理组和对照组小鼠的体重无差异。组织学分析显示，胃肠道和肝脏存在一些轻度的、特有的影响的证据，包括小部分(<40%)小鼠的坏死、脂肪变性和炎症。这可能是由于硫代色氨酸硫酸盐的首过肝代谢与吲哚的二次代谢相结合所致。然而，总体而言，含溴代吲哚的宝螺科提取物的口服给药不会导致严重的临床毒性。
