Department of Parasitic Diseases, National Centre for Disease Control, Delhi, India.
Jpn J Infect Dis. 2013;66(3):238-40. doi: 10.7883/yoken.66.238.
Lymphatic filariasis is the second leading cause of long-term disability in the world. In India, filariasis is endemic in 250 districts in 20 states and union territories with about 553 million people at risk of infection. Temephos is being used as a larvicide to control the population of Culex quinquefasciatus mosquito, the vector of bancroftian filariasis. The susceptibility status of Cx. quinquefasciatus to temephos in various urban zones of Delhi and the national capital region (NCR) was evaluated using the WHO standard susceptibility test kit. Results of the test revealed that the larval mortality in urban zones ranged from 2.8 to 56.5%, while that in rural zones ranged from 45.0 to 71.0%. Among the urban zones, the lowest larval mortality was recorded from Karol Bagh zone (2.8%) and highest mortality was recorded from Shahdara South zone (56.5%). In the NCR, the larvae were collected from the areas surrounding Delhi, and the larval mortality ranged from 75.0 to 87.5%. The present study indicates the possible development of resistance against temephos in the larvae of Cx. quinquefasciatus mosquitoes in some urban areas.
淋巴丝虫病是世界上导致长期残疾的第二大原因。在印度，有 20 个邦和联邦属地的 250 个区流行丝虫病，约有 5.53 亿人面临感染风险。噻苯达唑被用作杀幼虫剂来控制库蚊（致班氏丝虫病的病媒）的数量。使用世界卫生组织标准敏感性测试试剂盒评估了德里和国家首都地区（NCR）各城市地区库蚊对噻苯达唑的敏感性状况。测试结果显示，城市地区的幼虫死亡率在 2.8%至 56.5%之间，而农村地区的死亡率在 45.0%至 71.0%之间。在城市地区，死亡率最低的是卡罗尔巴格区（2.8%），死亡率最高的是沙德拉南区（56.5%）。在 NCR，幼虫是从德里周边地区收集的，幼虫死亡率在 75.0%至 87.5%之间。本研究表明，在一些城市地区，库蚊幼虫对噻苯达唑可能产生了抗药性。
