干细胞静止：活力、约束与细胞空闲。
Stem Cell Quiescence: Dynamism, Restraint, and Cellular Idling.
机构信息
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA; Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, CA, USA.
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA; Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, CA, USA; Center for Tissue Regeneration, Repair and Restoration, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.
出版信息
Cell Stem Cell. 2019 Feb 7;24(2):213-225. doi: 10.1016/j.stem.2019.01.001.
Stem cells can reside in a state of reversible growth arrest, or quiescence, for prolonged periods of time. Although quiescence has long been viewed as a dormant, low-activity state, increasing evidence suggests that quiescence represents states of poised potential and active restraint, as stem cells "idle" in anticipation of activation, proliferation, and differentiation. Improved understanding of quiescent stem cell dynamics is leading to novel approaches to enhance maintenance and repair of aged or diseased tissues. In this Review, we discuss recent advances in our understanding of stem cell quiescence and techniques enabling more refined analyses of quiescence in vivo.
干细胞可以处于可逆的生长停滞状态，即静止期，持续很长时间。尽管静止期长期以来被视为休眠、低活性状态，但越来越多的证据表明，静止期代表着潜在的准备状态和活跃的抑制状态，因为干细胞“闲置”以等待激活、增殖和分化。对静止期干细胞动力学的更好理解正在导致新的方法来增强对衰老或患病组织的维持和修复。在这篇综述中，我们讨论了我们对干细胞静止期的理解的最新进展，以及使我们能够更精细地分析体内静止期的技术。
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