Department of Nutritional Sciences, Nagoya University of Arts and Sciences, Nisshin, Japan.
J Nutr. 2013 Jul;143(7):1067-73. doi: 10.3945/jn.113.176636. Epub 2013 May 22.
We have shown that intake of sesame seed and its lignan increases vitamin E concentrations and decreases urinary excretion levels of vitamin E metabolites in male Wistar rats, suggesting inhibition of vitamin E catabolism by sesame lignan. The aim of this study was to examine whether dietary sesame seed also increased vitamin K concentrations, because its metabolic pathway is similar to that of vitamin E. To test the effect of sesame lignan on vitamin K concentrations, male Wistar rats were fed a control diet or a diet with 0.2% sesamin (a sesame lignan) for 7 d in experiment 1. Liver phylloquinone (PK), menaquinone-4 (MK-4), and γ-tocopherol were greater in rats fed sesamin than in control rats. To test the effect of sesame seed on vitamin K concentrations, male Wistar rats were fed a control diet or a diet with 1, 5, or 10% sesame seed for 3 d in experiment 2. Liver and kidney PK and γ-tocopherol but not MK-4 were greater in rats fed sesame seed than in control rats, although differences in dietary amounts of sesame seed did not affect the PK concentrations. For further confirmation of the effect of sesame seed, male Wistar rats were fed a control diet or a diet with 20% sesame seed for 40 d in experiment 3. Kidney, heart, lung, testis, and brain PK and brain MK-4 were greater in rats fed sesame seed than in control rats. The present study revealed for the first time, to our knowledge, that dietary sesame seed and sesame lignan increase not only vitamin E but also vitamin K concentrations in rat tissues.
我们已经表明，芝麻及其木脂素的摄入可以增加维生素 E 的浓度，并降低雄性 Wistar 大鼠尿液中维生素 E 代谢物的排泄水平，这表明芝麻木脂素抑制了维生素 E 的分解代谢。本研究的目的是检查饮食中的芝麻是否也能增加维生素 K 的浓度，因为它的代谢途径与维生素 E 相似。为了检验芝麻木脂素对维生素 K 浓度的影响，实验 1 中雄性 Wistar 大鼠连续 7 天分别喂食对照饲料或含 0.2%芝麻素（芝麻木脂素）的饲料。与对照组相比，喂食芝麻素的大鼠肝叶绿醌（PK）、甲萘醌-4（MK-4）和γ-生育酚的含量更高。为了检验芝麻对维生素 K 浓度的影响，实验 2 中雄性 Wistar 大鼠连续 3 天分别喂食对照饲料或含 1%、5%或 10%芝麻的饲料。与对照组相比，喂食芝麻的大鼠肝和肾 PK 和γ-生育酚的含量更高，但 MK-4 的含量没有差异，尽管芝麻的饮食量不同，但对 PK 浓度没有影响。为了进一步证实芝麻的作用，实验 3 中雄性 Wistar 大鼠连续 40 天喂食对照饲料或含 20%芝麻的饲料。与对照组相比，喂食芝麻的大鼠肾、心、肺、睾丸和脑 PK 以及脑 MK-4 的含量更高。本研究首次表明，饮食中的芝麻和芝麻木脂素不仅能增加维生素 E 的浓度，还能增加大鼠组织中维生素 K 的浓度。
