Shandra A A, Godlevsky L S
Department of Physiology, N I Pirogov Odessa Medical Institute, USSR.
Indian J Exp Biol. 1990 Feb;28(2):158-61.
It was shown in acute experiments on cats that high frequency (100-300 Hz) electrical stimulation of dentate nucleus led to the solitary epileptic foci of relatively weak intensity suppression and at the same time caused the activation of stronger focal epileptic activity. Electrical stimulation of nucleus dentatus suppressed the epileptic activity of grand mal type and increased seizures in rats with petit mal form of epileptogenesis which was formed in rats during pentylenetatiozol kindling. It was concluded that there is a relation between the antiepileptic effects of nucleus dentatus irritation and intensity as well as the form of epileptic activity induced experimentally.
在对猫的急性实验中表明，高频（100 - 300赫兹）电刺激齿状核会导致强度相对较弱的孤立癫痫病灶受到抑制，同时会引发较强局灶性癫痫活动的激活。电刺激齿状核可抑制大发作型癫痫活动，并增加在戊四氮点燃过程中大鼠形成的小发作型癫痫发生模型大鼠的癫痫发作。得出的结论是，齿状核刺激的抗癫痫作用与实验诱导的癫痫活动的强度以及形式之间存在关联。
