Kryzhanovskiĭ G N, Makul'kin R F, Shandra A A, Godlevskiĭ L S
Biull Eksp Biol Med. 1983 Mar;95(3):26-9.
It has been shown in acute experiments on cats that electrical stimulation (ES, 100-300 Hz) of the dentate nucleus leads to suppression of interictal discharges elicited by application of low concentrated penicillin solution to the neocortex. ES of the nucleus causes activation of discharges in a more powerful focus of seizures. As its activity gradually attenuates the seizure discharges are suppressed during ES. The period of focus existence is shortened by ES of the nucleus. ES of the ipsilateral nucleus produces no marked effect, leading only to the decreased frequency of seizure discharges. It is concluded that the dentate nucleus plays a significant role as part of the brain antiepileptic system.
在对猫进行的急性实验中发现，对齿状核进行电刺激（ES，100 - 300赫兹）可抑制向新皮质施加低浓度青霉素溶液所引发的发作间期放电。对该核的电刺激会在更强的癫痫发作灶中激活放电。随着其活动逐渐减弱，在电刺激期间癫痫发作放电会受到抑制。对该核的电刺激会缩短病灶存在的时间。对同侧核的电刺激没有显著效果，仅导致癫痫发作放电频率降低。得出的结论是，齿状核作为大脑抗癫痫系统的一部分发挥着重要作用。
