[Effect of electric stimulation of the dentate nucleus of the cerebellum on epileptogenic foci in the cerebral cortex].

It has been shown in acute experiments on cats that electrical stimulation (ES, 100-300 Hz) of the dentate nucleus leads to suppression of interictal discharges elicited by application of low concentrated penicillin solution to the neocortex. ES of the nucleus causes activation of discharges in a more powerful focus of seizures. As its activity gradually attenuates the seizure discharges are suppressed during ES. The period of focus existence is shortened by ES of the nucleus. ES of the ipsilateral nucleus produces no marked effect, leading only to the decreased frequency of seizure discharges. It is concluded that the dentate nucleus plays a significant role as part of the brain antiepileptic system.