[小脑齿状核低频电刺激对癫痫活动病灶的影响]
[Effect of low-frequency electric stimulation of the dentate nucleus of the cerebellum on foci of epileptic activity].
作者信息
Shandra A A, Godlevskiĭ L S
出版信息
Patol Fiziol Eksp Ter. 1989 May-Jun(3):24-8.
It was demonstrated in acute experiments on cats that low-frequency (7-12 Hz) electrical stimulation of the dentate nucleus of the cerebellum induces the formation of ictal discharges in foci of powerful epileptic activity produced in the brain cortex by application of penicillin solution. Ictal discharges were also provoked under the effect of electrical stimulation (7-12 Hz) of the ventrolateral nucleus of the thalamus. Destruction of the ventrolateral nucleus abolished the effect of ictal discharge facilitation induced by stimulation of the dentate nucleus. The results are discussed from the standpoint of increasing the efficacy of the stimulation method for arresting the epileptic syndrome.
在对猫进行的急性实验中证实，对小脑齿状核进行低频（7 - 12赫兹）电刺激，可在通过应用青霉素溶液在大脑皮层产生的强烈癫痫活动病灶中诱发发作性放电。在丘脑腹外侧核的电刺激（7 - 12赫兹）作用下也会引发发作性放电。丘脑腹外侧核的损毁消除了刺激齿状核所诱发的发作性放电促进作用。从提高抑制癫痫综合征刺激方法的疗效角度对结果进行了讨论。
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