CRA ex-INRAN, Via Ardeatina, 546, 00178 Rome, Italy.
Curr Pharm Des. 2014;20(6):1020-4. doi: 10.2174/138161282006140220144802.
Postprandial stress induced by acute consumption of meals with a high fat content results in an increase of markers of cardiometabolic risk. Repeated acute dietary stress may induce a persistent low-grade inflammation, playing a role in the pathogenesis of functional gut diseases. This may cause an impairment of the complex immune response of the gastrointestinal mucosa, which results in a breakdown of oral tolerance. We investigated the effect of ingestion of a fruit-juice drink (FJD) composed by multiple fruit juice and extracts, green tea extracts and vitamin C on postprandial stress induced by a High Fat Meal (HFM) in healthy overweight subjects. Following a double blind, placebo controlled, cross-over design, 15 healthy overweight subjects were randomized to a HFM providing 1334 Kcal (55% fat, 30% carbohydrates and 15% proteins) in combination with 500 mL of a placebo drink (HFM-P) or a fruit-juice drink (HFM-FJD). Ingestion of HFM-P led to an increase in circulating levels of cholesterol, triglycerides, glucose, insulin, TNF-α and IL-6. Ingestion of HFM-FJD significantly reduced plasma levels of cholesterol and triglycerides, decreasing inflammatory response mediated by TNF-α and IL-6. Ingestion of a fruit-juice drink reduce markers of postprandial stress induced by a HFM.
进食高脂肪含量的餐食会导致餐后应激，增加心血管代谢风险标志物。反复的急性饮食应激可能会引起持续的低度炎症，在功能性肠道疾病的发病机制中发挥作用。这可能导致胃肠道黏膜复杂免疫反应受损，从而破坏口服耐受性。我们研究了饮用由多种果汁和提取物、绿茶提取物和维生素 C 组成的果汁饮料 (FJD) 对健康超重受试者高脂肪餐 (HFM) 引起的餐后应激的影响。采用双盲、安慰剂对照、交叉设计，将 15 名健康超重受试者随机分为 HFM 组，给予 1334 卡路里的热量（55%脂肪、30%碳水化合物和 15%蛋白质），并与 500 毫升安慰剂饮料（HFM-P）或果汁饮料（HFM-FJD）联合使用。HFM-P 的摄入导致胆固醇、甘油三酯、葡萄糖、胰岛素、TNF-α 和 IL-6 的循环水平升高。HFM-FJD 的摄入显著降低了胆固醇和甘油三酯的血浆水平，降低了 TNF-α 和 IL-6 介导的炎症反应。饮用果汁饮料可降低 HFM 引起的餐后应激标志物。
