Antioxidant Research Laboratory, INRAN Via Ardeatina 546, 00178 Rome, Italy.
Curr Pharm Des. 2012;18(1):85-90. doi: 10.2174/138161212798919020.
An emerging role of IL-17 in the inflammatory response associated with pathogenesis of neurodegeneration has been recently suggested. However, though diet represents a key factor in the modulation of inflammatory processes, evidence is not currently available on the nutritional regulation of IL-17 in humans. In a double blind, randomized, placebo controlled, crossover study, we investigated the effect of High Fat Meal (HFM) on IL-17 circulating levels in presence of a placebo (HFM-P) or with a Fruit Juice Drink (HFM-FJD) composed of pineapple, blackcurrant and plum in fourteen healthy overweight humans. Fasting in the morning subjects ingested a test meal providing 1344 Kcal. Ingestion of HFM-P induced an inflammatory response mediated by TNF-α (p < 0.001), IL-6 (p < 0.001) and IL-17 (p < 0.01). Plasma IL-17 concentration significantly increased at 1 h (+2.6 ± 1.1 pg/ml), remaining high at 4 h (+2.98 ± 1.2 pg/ml), 6 h (+2.38 ± 0.6 pg/ml) and 8 h (+2.8 ± 0.9 pg/ml) (ANOVA for time-course p=0.009). When the HFM was consumed in the presence of the FJD a marked inhibition of IL-17 response to the HFM was observed (ANOVA between treatment p=0.037). We provided, for the first time, evidence on the role of diet in modulating IL-17 production in healthy overweight subjects.
最近有研究表明，白细胞介素 17（IL-17）在与神经退行性病变发病机制相关的炎症反应中发挥着重要作用。然而，尽管饮食是调节炎症过程的关键因素，但目前尚无关于人类 IL-17 营养调节的证据。在一项双盲、随机、安慰剂对照、交叉研究中，我们调查了高脂餐（HFM）对 14 名健康超重人群中白细胞介素 17 循环水平的影响，这些人在摄入安慰剂（HFM-P）或含有菠萝、黑加仑和李子的果汁饮料（HFM-FJD）时。在早晨空腹的情况下，受试者摄入了提供 1344 卡路里的测试餐。HFM-P 的摄入会引起 TNF-α（p<0.001）、IL-6（p<0.001）和 IL-17（p<0.01）介导的炎症反应。HFM-P 摄入后，血浆 IL-17 浓度在 1 小时时显著升高（+2.6±1.1pg/ml），在 4 小时（+2.98±1.2pg/ml）、6 小时（+2.38±0.6pg/ml）和 8 小时（+2.8±0.9pg/ml）时仍保持高水平（时间过程的 ANOVA，p=0.009）。当 HFM 与 FJD 一起摄入时，观察到对 HFM 反应的 IL-17 抑制作用明显（治疗之间的 ANOVA，p=0.037）。我们首次提供了饮食在调节健康超重人群中 IL-17 产生方面的作用的证据。
