Kurtoğlu Ertuğrul, Aktürk Erdal, Korkmaz Hasan, Sincer Isa, Yılmaz Mücahid, Erdem Kenan, Celik Ahmet, Ozdemir Ramazan
Department of Cardiology, Elazığ Training and Research Hospital, Elazığ, Turkey.
Turk Kardiyol Dern Ars. 2013 Apr;41(3):199-206. doi: 10.5543/tkda.2013.42375.
Red blood cell distribution width (RDW) has been reported to be a marker of morbidity and mortality for some cardiovascular and pulmonary diseases. We aimed to evaluate RDW values in otherwise healthy smokers.
Two hundred and twenty consecutive subjects with current smoking and 230 age- and gender-matched healthy subjects without smoking history were enrolled. Number of cigarettes smoked per day and duration of smoking, evaluated as pack years, were recorded. Complete blood count, high-sensitivity C-reactive protein (hs-CRP) levels and lipid profile were analyzed in all study participants.
The mean RDW values were higher in smokers than in nonsmokers (13.9±1.2 vs. 13.1±0.8, p<0.0001). The mean leukocyte count, mean platelet volume and hs-CRP levels were also significantly greater in smokers when compared to nonsmokers (8440±1.750 vs. 7090±1550, p<0.0001; 8.7±0.8 fL vs. 8.3±0.6 fL, p<0.0001; 2.42±0.53 mg/L vs. 1.46±0.52 mg/L, p<0.0001, respectively). Significant positive correlations between RDW and number of cigarettes smoked per day and between RDW and duration of smoking were identified (r=0.565 and r=0.305, respectively).
Elevated RDW is associated with cigarette smoking and may be a useful indicator of inflammatory activity in smokers.
据报道，红细胞分布宽度（RDW）是一些心血管和肺部疾病发病和死亡的标志物。我们旨在评估健康吸烟者的RDW值。
纳入220名连续的当前吸烟者和230名年龄和性别匹配且无吸烟史的健康受试者。记录每日吸烟量和吸烟持续时间（以包年计算）。对所有研究参与者进行全血细胞计数、高敏C反应蛋白（hs-CRP）水平和血脂分析。
吸烟者的平均RDW值高于非吸烟者（13.9±1.2对13.1±0.8，p<0.0001）。与非吸烟者相比，吸烟者的平均白细胞计数、平均血小板体积和hs-CRP水平也显著更高（分别为8440±1750对7090±1550，p<0.0001；8.7±0.8 fL对8.3±0.6 fL，p<0.0001；2.42±0.53 mg/L对1.46±0.52 mg/L，p<0.0001）。发现RDW与每日吸烟量以及RDW与吸烟持续时间之间存在显著正相关（分别为r=0.565和r=0.305）。
RDW升高与吸烟有关，可能是吸烟者炎症活动的一个有用指标。
