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Adverse events following administration to pregnant women of influenza A (H1N1) 2009 monovalent vaccine reported to the Vaccine Adverse Event Reporting System.向疫苗不良事件报告系统报告的孕妇接种甲型 H1N1 流感 2009 单价疫苗后的不良事件。
Am J Obstet Gynecol. 2011 Nov;205(5):473.e1-9. doi: 10.1016/j.ajog.2011.06.047. Epub 2011 Jun 21.
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Influenza vaccination coverage among pregnant women --- United States, 2010-11 influenza season.孕妇流感疫苗接种率——美国,2010-2011 年流感季节。
MMWR Morb Mortal Wkly Rep. 2011 Aug 19;60(32):1078-82.
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Perinatal outcomes after maternal 2009/H1N1 infection: national cohort study.母亲感染 2009/H1N1 后的围产期结局:全国队列研究。
BMJ. 2011 Jun 14;342:d3214. doi: 10.1136/bmj.d3214.
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Maternal influenza immunization and reduced likelihood of prematurity and small for gestational age births: a retrospective cohort study.母亲流感免疫接种与早产和小于胎龄儿出生几率降低相关:一项回顾性队列研究。
PLoS Med. 2011 May;8(5):e1000441. doi: 10.1371/journal.pmed.1000441. Epub 2011 May 31.
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Influenza vaccination coverage among pregnant women--National 2009 H1N1 Flu Survey (NHFS).孕妇人群中的流感疫苗接种率——2009 年全国甲型 H1N1 流感调查(NHFS)。
Am J Obstet Gynecol. 2011 Jun;204(6 Suppl 1):S96-106. doi: 10.1016/j.ajog.2011.03.003. Epub 2011 Mar 9.
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Effect of respiratory hospitalization during pregnancy on infant outcomes.妊娠期间呼吸系统住院对婴儿结局的影响。
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Monitoring vaccine safety using the Vaccine Safety Datalink: utilizing immunization registries for pandemic influenza.利用疫苗安全数据链接监测疫苗安全性:利用免疫登记系统进行大流行性流感。
Vaccine. 2011 Jul 12;29(31):4891-6. doi: 10.1016/j.vaccine.2011.05.003. Epub 2011 May 17.
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Pandemic 2009 influenza A (H1N1) in 71 critically ill pregnant women in California.加利福尼亚州 71 例危重症孕妇感染 2009 年甲型 H1N1 流感大流行。
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Novel pandemic A (H1N1) influenza vaccination among pregnant women: motivators and barriers.新型甲型 H1N1 流感在孕妇中的疫苗接种:动机和障碍。
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2008年至2012年孕妇流感疫苗接种率趋势

Trends in influenza vaccine coverage in pregnant women, 2008 to 2012.

作者信息

Henninger Michelle, Crane Bradley, Naleway Allison

机构信息

Senior Research Associate at The Center for Health Research in Portland, OR, USA.

出版信息

Perm J. 2013 Spring;17(2):31-6. doi: 10.7812/TPP/12-115.

DOI:10.7812/TPP/12-115
PMID:23704840
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3662276/
Abstract

CONTEXT

Pregnant women are at increased risk of severe influenza-related complications and hospitalizations and are a priority group for influenza vaccination.

OBJECTIVE

To examine coverage of seasonal and pandemic influenza A (H1N1) vaccines in pregnant women in a managed care setting, from 2008 to 2012.

DESIGN

Retrospective cohort study of 10,145 pregnant women.

MAIN OUTCOME MEASURES

H1N1 and seasonal influenza vaccination rates.

RESULTS

Seasonal influenza vaccine coverage increased from 38% to 63% between the 2008-2009 and 2010-2011 seasons, and then dropped to 61% in 2011-2012. Vaccine coverage was higher in women considered at high risk of influenza complications, increasing from 43% in 2008-2009 to 71% in 2010-2011, before decreasing to 69% in 2011-2012. H1N1 vaccine coverage was greater than seasonal influenza coverage in 2009-2010 in the overall pregnant population (61% vs 53%) and in the high-risk group (64% vs 59%). We observed statistically significant differences in vaccination rates by trimester, gravidity, maternal age, and race/ethnicity.

CONCLUSIONS

Vaccination rates increased significantly from 2008 to 2011, then dropped slightly in 2011-2012. Continued efforts are needed to ensure adequate vaccination coverage in this high-risk population.

摘要

背景

孕妇患严重流感相关并发症和住院的风险增加,是流感疫苗接种的重点人群。

目的

研究2008年至2012年在管理式医疗环境中孕妇接种季节性流感疫苗和甲型H1N1流感大流行疫苗的覆盖率。

设计

对10145名孕妇进行回顾性队列研究。

主要观察指标

甲型H1N1流感和季节性流感疫苗接种率。

结果

2008 - 2009年至2010 - 2011年期间,季节性流感疫苗覆盖率从38%升至63%,然后在2011 - 2012年降至61%。被认为患流感并发症高危的女性疫苗覆盖率更高,从2008 - 2009年的43%增至2010 - 2011年的71%,之后在2011 - 2012年降至69%。在2009 - 2010年,总体孕妇人群(61%对53%)和高危组(64%对59%)中,甲型H1N1流感疫苗覆盖率高于季节性流感疫苗覆盖率。我们观察到不同孕期、妊娠次数、产妇年龄和种族/族裔的疫苗接种率存在统计学显著差异。

结论

2008年至2011年疫苗接种率显著上升,然后在2011 - 2012年略有下降。需要持续努力以确保这一高危人群有足够的疫苗接种覆盖率。