Kim Ki Jung, Park Eun Sook, Chang Hyun Jung, Suh Miri, Rha Dong-Wook
Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul, Korea.
Ann Rehabil Med. 2013 Apr;37(2):286-90. doi: 10.5535/arm.2013.37.2.286. Epub 2013 Apr 30.
Several cases of acute necrotizing encephalopathy (ANE) with influenza A (H1N1) have been reported to date. The prognosis of ANE associated with H1N1 is variable; some cases resulted in severe neurologic complication, whereas other cases were fatal. Reports mostly focused on the diagnosis of ANE with H1N1 infection, rather than functional recovery. We report a case of ANE with H1N1 infection in a 4-year-old Korean girl who rapidly developed fever, seizure, and altered mentality, as well as had neurologic sequelae of ataxia, intentional tremor, strabismus, and dysarthria. Brain magnetic resonance imaging showed lesions in the bilateral thalami, pons, and left basal ganglia. To our knowledge, this is the first report of ANE caused by H1N1 infection and its long-term functional recovery in Korea.
迄今为止，已有数例甲型H1N1流感相关的急性坏死性脑病（ANE）病例报告。与H1N1相关的ANE预后各不相同；一些病例出现了严重的神经并发症，而其他病例则是致命的。报告大多集中在H1N1感染相关的ANE诊断上，而非功能恢复情况。我们报告了一名4岁韩国女孩患H1N1感染相关ANE的病例，她迅速出现发热、惊厥和意识改变，以及共济失调、意向性震颤、斜视和构音障碍等神经后遗症。脑磁共振成像显示双侧丘脑、脑桥和左侧基底节有病变。据我们所知，这是韩国首例由H1N1感染引起的ANE及其长期功能恢复的报告。
