Hildebrand R, Irrgang U, Saath K
Anaesthesist. 1977 Dec;26(12):659-61.
A significant decrease was observed in nuclear volume of the follicular cells of the thyroid gland and the cells of the parathyroid of albino rats subjected to ether anaesthesia, in contrast to generally unchanged nuclear size in animals anaesthetized by thiobutabarbitone sodium. It is suggested that ether exerts its depressant influence mainly by direct action on the function of the follicular cells of the thyroid. Thiobutabarbitone Sodium probably influences thyroid function especially by its antithyroid-drug effects, which have been reported by other authors. The highly significant increase of nuclear volume in the tracheal glands during ether narcosis is referred to the mucous secretion activating stimulus of ether vapors.
与用硫喷妥钠麻醉的动物细胞核大小普遍未变形成对比的是,观察到经乙醚麻醉的白化大鼠甲状腺滤泡细胞和甲状旁腺细胞的细胞核体积显著减小。有人认为,乙醚主要通过直接作用于甲状腺滤泡细胞的功能发挥其抑制作用。硫喷妥钠可能尤其通过其抗甲状腺药物作用影响甲状腺功能,其他作者已有相关报道。乙醚麻醉期间气管腺细胞核体积的极显著增加归因于乙醚蒸汽对黏液分泌的激活刺激。