Department of Food Science and Biotechnology, National Chung Hsing University, 250 Kuokuang Road, Taichung 40227, Taiwan, ROC.
Food Chem Toxicol. 2013 Aug;58:416-22. doi: 10.1016/j.fct.2013.05.018. Epub 2013 May 22.
To unravel possible protective effects of a newly isolated lotus plumule polysaccharide (LPPS) on type 1 diabetes (T1D), this study isolated LPPS and administered it to non-obese diabetic (NOD) female mice for 15 weeks. Oral glucose tolerance, serum ketone body, glucose, insulin, and lipid levels, as well as pancreatic islet cell numbers and the insulin secretion ability of the experimental mice were determined. The results showed that LPPS administration in vivo significantly (P<0.05) increased pancreatic islet cell numbers and slightly enhanced the basal insulin secretion ability compared to the control group. LPPS administration improved serum lipid profiles in the diabetic mice via relatively increasing serum high density lipoprotein-cholesterol, but decreasing low density lipoprotein-cholesterol and total cholesterol levels. The present study suggests that LPPS supplementation may ameliorate T1D progress and its complications through protecting pancreatic islets and modulating serum lipid profiles.
为了揭示新分离的莲须多糖（LPPS）对 1 型糖尿病（T1D）可能的保护作用，本研究分离了 LPPS 并在 15 周内给予非肥胖型糖尿病（NOD）雌性小鼠。测定了实验小鼠的口服葡萄糖耐量、血清酮体、血糖、胰岛素和血脂水平以及胰岛细胞数量和胰岛素分泌能力。结果表明，与对照组相比，体内给予 LPPS 显著（P<0.05）增加了胰岛细胞数量，并略微增强了基础胰岛素分泌能力。LPPS 给药通过相对增加血清高密度脂蛋白胆固醇，降低低密度脂蛋白胆固醇和总胆固醇水平，改善了糖尿病小鼠的血清脂质谱。本研究表明，LPPS 补充可能通过保护胰岛和调节血清脂质谱来改善 T1D 进展及其并发症。
