School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, New South Wales 2052, Australia; Département de Biologie Intégrative, Université du Québec à Rimouski, Rimouski, QC, Canada.
Mitochondrion. 2013 Nov;13(6):817-22. doi: 10.1016/j.mito.2013.05.008. Epub 2013 May 23.
In this study, we examine the dietary protein to carbohydrate ratio (P:C) on the mitochondrial functions of two Drosophila melanogaster mtDNA haplotypes. We investigated multiple physiological parameters on flies fed with either 1:12 P:C or 1:3 P:C diets. Our results provide experimental evidence that a specific haplotype has a reduction of complex I activity when the flies are fed with the 1:12 P:C diet. This study is of particular importance to understand the influence of diet on mitochondrial evolution in invasive and broadly distributed species including humans.
在这项研究中，我们研究了膳食蛋白质与碳水化合物的比例（P:C）对两种黑腹果蝇 mtDNA 单倍型线粒体功能的影响。我们研究了喂食 1:12 P:C 或 1:3 P:C 饮食的果蝇的多个生理参数。我们的结果提供了实验证据，表明当果蝇喂食 1:12 P:C 饮食时，特定的单倍型的复合物 I 活性降低。这项研究对于理解饮食对包括人类在内的入侵性和广泛分布物种的线粒体进化的影响具有特别重要的意义。
