SPDEF: a molecular switch for E-cadherin expression that promotes prostate cancer metastasis.
作者信息
Osisami Mary, Keller Evan T
出版信息
Asian J Androl. 2013 Sep;15(5):584-5. doi: 10.1038/aja.2013.64. Epub 2013 May 27.
Abstract
摘要
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SPDEF: a molecular switch for E-cadherin expression that promotes prostate cancer metastasis.SPDEF：一种促进前列腺癌转移的E-钙黏蛋白表达的分子开关。
Asian J Androl. 2013 Sep;15(5):584-5. doi: 10.1038/aja.2013.64. Epub 2013 May 27.
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A tight junction between E-Cadherin and the prostate tumor suppressor SPDEF.E-钙黏蛋白与前列腺肿瘤抑制因子SPDEF之间的紧密连接。
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The transcription factor sterile alpha motif (SAM) pointed domain-containing ETS transcription factor (SPDEF) is required for E-cadherin expression in prostate cancer cells.转录因子 sterile alpha motif (SAM) 结构域包含 ETS 转录因子 (SPDEF) 是前列腺癌细胞中 E-钙黏蛋白表达所必需的。
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The transcription factor SPDEF suppresses prostate tumor metastasis.转录因子 SPDEF 抑制前列腺肿瘤转移。
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GADD45α and γ interaction with CDK11p58 regulates SPDEF protein stability and SPDEF-mediated effects on cancer cell migration.GADD45α和γ与CDK11p58的相互作用调节SPDEF蛋白稳定性以及SPDEF对癌细胞迁移的介导作用。
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Loss of SPDEF and gain of TGFBI activity after androgen deprivation therapy promote EMT and bone metastasis of prostate cancer.雄激素剥夺治疗后 SPDEF 的缺失和 TGFBI 活性的获得促进前列腺癌的 EMT 和骨转移。
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Upregulation of prostate-derived Ets factor by luteolin causes inhibition of cell proliferation and cell invasion in prostate carcinoma cells.木樨草素通过上调前列腺衍生的 Ets 因子导致前列腺癌细胞增殖和细胞侵袭的抑制。
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ZEB1 Collaborates with ELK3 to Repress E-Cadherin Expression in Triple-Negative Breast Cancer Cells.ZEB1 与 ELK3 合作抑制三阴性乳腺癌细胞中 E-钙黏蛋白的表达。
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SAM pointed domain ETS factor (SPDEF) regulates terminal differentiation and maturation of intestinal goblet cells.SAM 指向结构域 ETS 因子 (SPDEF) 调节肠道杯状细胞的终末分化和成熟。
Exp Cell Res. 2010 Feb 1;316(3):452-65. doi: 10.1016/j.yexcr.2009.09.020. Epub 2009 Sep 26.
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Signatures of prostate-derived Ets factor (PDEF) in cancer.前列腺源性Ets因子（PDEF）在癌症中的特征。
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本文引用的文献
1
The transcription factor sterile alpha motif (SAM) pointed domain-containing ETS transcription factor (SPDEF) is required for E-cadherin expression in prostate cancer cells.转录因子 sterile alpha motif (SAM) 结构域包含 ETS 转录因子 (SPDEF) 是前列腺癌细胞中 E-钙黏蛋白表达所必需的。
J Biol Chem. 2013 Apr 26;288(17):12222-31. doi: 10.1074/jbc.M112.434225. Epub 2013 Feb 28.
2
The transcription factor SPDEF suppresses prostate tumor metastasis.转录因子 SPDEF 抑制前列腺肿瘤转移。
J Biol Chem. 2012 Aug 24;287(35):29968-78. doi: 10.1074/jbc.M112.379396. Epub 2012 Jul 2.
3
E-cadherin's dark side: possible role in tumor progression.E-钙黏蛋白的阴暗面：在肿瘤进展中的可能作用。
Biochim Biophys Acta. 2012 Aug;1826(1):23-31. doi: 10.1016/j.bbcan.2012.03.002. Epub 2012 Mar 13.
4
Cancer invasion and the microenvironment: plasticity and reciprocity.癌症侵袭与微环境：可塑性与互为影响。
Cell. 2011 Nov 23;147(5):992-1009. doi: 10.1016/j.cell.2011.11.016.
5
Prostate-derived Ets transcription factor (PDEF) is a potential prognostic marker in patients with prostate cancer.前列腺衍生的 Ets 转录因子 (PDEF) 是前列腺癌患者的潜在预后标志物。
Prostate. 2011 Aug 1;71(11):1178-88. doi: 10.1002/pros.21333. Epub 2011 Jan 12.
6
Hallmarks of cancer: the next generation.癌症的特征：下一代。
Cell. 2011 Mar 4;144(5):646-74. doi: 10.1016/j.cell.2011.02.013.
7
Molecular genetics of prostate cancer: new prospects for old challenges.前列腺癌的分子遗传学：旧挑战的新展望。
Genes Dev. 2010 Sep 15;24(18):1967-2000. doi: 10.1101/gad.1965810.
8
Breast carcinoma cells re-express E-cadherin during mesenchymal to epithelial reverting transition.乳腺癌细胞在间质到上皮逆转转化过程中重新表达 E-钙黏蛋白。
Mol Cancer. 2010 Jul 7;9:179. doi: 10.1186/1476-4598-9-179.
9
Loss of PDEF, a prostate-derived Ets factor is associated with aggressive phenotype of prostate cancer: regulation of MMP 9 by PDEF.PDEF 的缺失与前列腺癌侵袭性表型有关：PDEF 对 MMP9 的调控。
Mol Cancer. 2010 Jun 15;9:148. doi: 10.1186/1476-4598-9-148.
10
Expression characteristics of prostate-derived Ets factor support a role in breast and prostate cancer progression.前列腺源性Ets因子的表达特征支持其在乳腺癌和前列腺癌进展中的作用。
Hum Pathol. 2007 Nov;38(11):1628-38. doi: 10.1016/j.humpath.2007.03.010. Epub 2007 May 22.
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