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葡萄籽原花青素提取物对大鼠非甾体抗炎药诱导的胃损伤的胃保护作用。

Gastroprotective Effects of Grape Seed Proanthocyanidin Extracts against Nonsteroid Anti-Inflammatory Drug-Induced Gastric Injury in Rats.

机构信息

Department of Internal Medicine, Catholic Research Institute of Medical Sciences, The Catholic University of Korea College of Medicine, Seoul, Korea.

出版信息

Gut Liver. 2013 May;7(3):282-9. doi: 10.5009/gnl.2013.7.3.282. Epub 2013 Apr 9.

DOI:10.5009/gnl.2013.7.3.282
PMID:23710308
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3661959/
Abstract

BACKGROUND/AIMS: To investigate the gastroprotective effects of grape seed proanthocyanidin extracts (GSPEs) against nonsteroid anti-inflammatory drug (NSAID)-induced gastric mucosal injury in rats.

METHODS

Sprague-Dawley rats were randomly allocated to the normal control, indomethacin, low-dose GSPE, high-dose GSPE and misoprostol groups. All groups except the normal control group received pretreatment drugs for 6 consecutive days. On the 5th and 6th day, indomethacin was administered orally to all groups except for normal control group. The microscopic features of injury were analyzed. The levels of gastric mucosal glutathione, gastric mucosal prostaglandin E2 (PGE2), and proinflammatory cytokines were investigated.

RESULTS

The total areas of ulceration in the GSPE and misoprostol groups were significantly decreased compared with the indomethacin group (p<0.05). However, a difference in ulcer formation among the drug treatment groups was not observed. Meanwhile, the glutathione levels in the high-dose GSPE group were higher than those of both the indomethacin and misoprostol groups (p<0.05) and were similar to those of the normal control group. Additionally, there was no difference among the groups in the levels of gastric mucosal PGE2 and proinflammatory cytokines.

CONCLUSIONS

High-dose GSPE has a strong protective effect against NSAID-induced gastric mucosal injury, which may be associated with the antioxidant effects of GSPE.

摘要

背景/目的：研究葡萄籽原花青素提取物（GSPE）对大鼠非甾体抗炎药（NSAID）诱导的胃黏膜损伤的胃保护作用。

方法

将 Sprague-Dawley 大鼠随机分为正常对照组、吲哚美辛组、低剂量 GSPE 组、高剂量 GSPE 组和米索前列醇组。除正常对照组外，所有组均连续预处理 6 天。在第 5 天和第 6 天，除正常对照组外，所有组均口服给予吲哚美辛。分析损伤的微观特征。研究胃黏膜谷胱甘肽、胃黏膜前列腺素 E2（PGE2）和促炎细胞因子的水平。

结果

GSPE 和米索前列醇组的溃疡总面积明显低于吲哚美辛组（p<0.05）。然而，药物治疗组之间的溃疡形成没有差异。同时，高剂量 GSPE 组的谷胱甘肽水平高于吲哚美辛组和米索前列醇组（p<0.05），与正常对照组相似。此外，各组胃黏膜 PGE2 和促炎细胞因子水平无差异。

结论

高剂量 GSPE 对 NSAID 诱导的胃黏膜损伤具有较强的保护作用，这可能与 GSPE 的抗氧化作用有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4c/3661959/eec4ff4b5a0a/gnl-7-282-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4c/3661959/ffc636458243/gnl-7-282-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4c/3661959/ca232e60fc90/gnl-7-282-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4c/3661959/18cc0caf868c/gnl-7-282-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4c/3661959/195ed28e0ccd/gnl-7-282-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4c/3661959/b74bbf4025d9/gnl-7-282-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4c/3661959/eec4ff4b5a0a/gnl-7-282-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4c/3661959/ffc636458243/gnl-7-282-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4c/3661959/ca232e60fc90/gnl-7-282-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4c/3661959/18cc0caf868c/gnl-7-282-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4c/3661959/195ed28e0ccd/gnl-7-282-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4c/3661959/b74bbf4025d9/gnl-7-282-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4c/3661959/eec4ff4b5a0a/gnl-7-282-g006.jpg

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