DNA纳米技术：只是一种新奇事物还是一项有前途的技术？
DNA nanotechnology: a curiosity or a promising technology?
作者信息
Tørring Thomas, Gothelf Kurt V
机构信息
Center for DNA Nanotechnology (CDNA) at the Interdisciplinary Nanoscience Center (iNANO), Aarhus University 8000 Aarhus C Denmark.
出版信息
F1000Prime Rep. 2013 May 1;5:14. doi: 10.12703/P5-14. Print 2013.
Abstract
DNA nanotechnology, the design and self-assembly of artificial nucleic acid-based structures or systems, has developed with breathtaking pace in recent years. The technology offers an unparalleled ability to control structure and function at the molecular level and the sizes of the structures are expanding towards the micrometer domain. The question is whether the technology offers solutions to any real-life problems, or if it will remain an academic discipline. Here, we discuss this question by extrapolating from recent developments in the field.
摘要
DNA纳米技术，即人工核酸基结构或系统的设计与自组装，近年来发展速度惊人。该技术在分子水平上具备无与伦比的控制结构和功能的能力，且结构尺寸正朝着微米领域扩展。问题在于这项技术能否解决任何实际问题，还是会一直停留在学术范畴。在此，我们通过推断该领域的最新进展来探讨这个问题。
相似文献
1
DNA nanotechnology: a curiosity or a promising technology?DNA纳米技术：只是一种新奇事物还是一项有前途的技术？
F1000Prime Rep. 2013 May 1;5:14. doi: 10.12703/P5-14. Print 2013.
2
DNA nanotechnology based on i-motif structures.基于 i -motif 结构的 DNA 纳米技术。
Acc Chem Res. 2014 Jun 17;47(6):1853-60. doi: 10.1021/ar500073a. Epub 2014 May 20.
3
Building DNA nanostructures for molecular computation, templated assembly, and biological applications.用于分子计算、模板组装和生物应用的 DNA 纳米结构构建。
Acc Chem Res. 2014 Jun 17;47(6):1778-88. doi: 10.1021/ar500023b. Epub 2014 Apr 10.
4
Towards Active Self-Assembly Through DNA Nanotechnology.通过 DNA 纳米技术实现主动自组装。
Top Curr Chem (Cham). 2020 Mar 12;378(2):33. doi: 10.1007/s41061-020-0297-5.
5
Emerging Biomimetic Applications of DNA Nanotechnology.DNA 纳米技术的新兴仿生应用。
ACS Appl Mater Interfaces. 2019 Apr 17;11(15):13859-13873. doi: 10.1021/acsami.8b06175. Epub 2018 Jun 25.
6
Structural DNA nanotechnology for intelligent drug delivery.结构 DNA 纳米技术在智能药物输送中的应用。
Small. 2014 Nov;10(22):4626-35. doi: 10.1002/smll.201401309. Epub 2014 Jun 23.
7
DNA block copolymers: functional materials for nanoscience and biomedicine.DNA 嵌段共聚物：用于纳米科学和生物医学的功能材料。
Acc Chem Res. 2012 Sep 18;45(9):1419-30. doi: 10.1021/ar200211a. Epub 2012 Jun 22.
8
Autonomous dynamic control of DNA nanostructure self-assembly.DNA 纳米结构自组装的自主动态控制。
Nat Chem. 2019 Jun;11(6):510-520. doi: 10.1038/s41557-019-0251-8. Epub 2019 Apr 22.
9
Macromolecular crowding: chemistry and physics meet biology (Ascona, Switzerland, 10-14 June 2012).大分子拥挤现象：化学与物理邂逅生物学（瑞士阿斯科纳，2012年6月10日至14日）
Phys Biol. 2013 Aug;10(4):040301. doi: 10.1088/1478-3975/10/4/040301. Epub 2013 Aug 2.
10
Gigadalton-scale shape-programmable DNA assemblies.吉加达尔顿规模的形状可编程 DNA 组装。
Nature. 2017 Dec 6;552(7683):78-83. doi: 10.1038/nature24651.
引用本文的文献
1
Exploring Advanced CRISPR Delivery Technologies for Therapeutic Genome Editing.探索用于治疗性基因组编辑的先进CRISPR递送技术。
Small Sci. 2024 Jul 25;4(10):2400192. doi: 10.1002/smsc.202400192. eCollection 2024 Oct.
2
A DNA-based nanocarrier for efficient cancer therapy.一种用于高效癌症治疗的基于DNA的纳米载体。
J Pharm Anal. 2021 Jun;11(3):330-339. doi: 10.1016/j.jpha.2020.03.005. Epub 2020 Mar 9.
本文引用的文献
1
Rapid folding of DNA into nanoscale shapes at constant temperature.在恒温下快速将 DNA 折叠成纳米形状。
Science. 2012 Dec 14;338(6113):1458-61. doi: 10.1126/science.1229919.
2
DNA origami templated self-assembly of discrete length single wall carbon nanotubes.DNA 折纸模板指导离散长度单壁碳纳米管的自组装。
Org Biomol Chem. 2013 Jan 28;11(4):596-8. doi: 10.1039/c2ob26942b. Epub 2012 Dec 3.
3
Three-dimensional structures self-assembled from DNA bricks.由 DNA 积木自组装形成的三维结构。
Science. 2012 Nov 30;338(6111):1177-83. doi: 10.1126/science.1227268.
4
Synthetic lipid membrane channels formed by designed DNA nanostructures.由设计的 DNA 纳米结构形成的人工脂质膜通道。
Science. 2012 Nov 16;338(6109):932-6. doi: 10.1126/science.1225624.
5
Purification of DNA-origami nanostructures by rate-zonal centrifugation.通过速率区带离心法纯化 DNA 折纸纳米结构。
Nucleic Acids Res. 2013 Jan;41(2):e40. doi: 10.1093/nar/gks1070. Epub 2012 Nov 15.
6
Fluorescence enhancement at docking sites of DNA-directed self-assembled nanoantennas.DNA 导向自组装纳米天线对接位点的荧光增强。
Science. 2012 Oct 26;338(6106):506-10. doi: 10.1126/science.1228638.
7
DNA origami delivery system for cancer therapy with tunable release properties.DNA 折纸递送系统用于癌症治疗，具有可调释药性能。
ACS Nano. 2012 Oct 23;6(10):8684-91. doi: 10.1021/nn3022662. Epub 2012 Sep 13.
8
DNA origami as a carrier for circumvention of drug resistance.DNA 折纸术作为克服耐药性的载体。
J Am Chem Soc. 2012 Aug 15;134(32):13396-403. doi: 10.1021/ja304263n. Epub 2012 Aug 1.
9
Complex shapes self-assembled from single-stranded DNA tiles.由单链 DNA 瓦片自组装而成的复杂形状。
Nature. 2012 May 30;485(7400):623-6. doi: 10.1038/nature11075.
10
Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery.分子自组装核酸纳米颗粒用于靶向体内 siRNA 递送。
Nat Nanotechnol. 2012 Jun 3;7(6):389-93. doi: 10.1038/nnano.2012.73.
Zotero 插件