Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China; Key Laboratory for Organic Electronics & Information Displays (KLOEID), Institute of Advanced Materials (IAM) and School of Materials Science and Engineering, Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing, 210046, China.
Small. 2014 Nov;10(22):4626-35. doi: 10.1002/smll.201401309. Epub 2014 Jun 23.
Drug delivery carriers have been popularly employed to improve solubility, stability, and efficacy of chemical and biomolecular drugs. Despite the rapid progress in this field, it remains a great challenge to develop an ideal carrier with minimal cytotoxicity, high biocompatibility and intelligence for targeted controlled release. The emergence of DNA nanotechnology offers unprecedented opportunities in this regard. Due to the unparalleled self-recognition properties of DNA molecules, it is possible to create numerous artificial DNA nanostructures with well-defined structures and DNA nanodevices with precisely controlled motions. More importantly, recent studies have proven that DNA nanostructures possess greater permeability to the membrane barrier of cells, which pave the way to developing new drug delivery carriers with nucleic acids, are summarized. In this Concept, recent advances on the design and fabrication of both static and dynamic DNA nanostructures, and the use of these nanostructures for the delivery of various types of drugs, are highlighted. It is also demonstrated that dynamic DNA nanostructures provide the required intelligence to realize logically controlled drug release.
药物输送载体被广泛用于提高化学和生物分子药物的溶解度、稳定性和功效。尽管该领域取得了快速进展，但开发具有最小细胞毒性、高生物相容性和智能靶向控制释放的理想载体仍然是一个巨大的挑战。DNA 纳米技术的出现为此提供了前所未有的机会。由于 DNA 分子具有无与伦比的自我识别特性，因此可以创建具有明确定义结构的众多人工 DNA 纳米结构和具有精确控制运动的 DNA 纳米器件。更重要的是，最近的研究证明，DNA 纳米结构对细胞的膜屏障具有更大的通透性，这为开发具有核酸的新型药物输送载体铺平了道路，对此进行了总结。在本综述中，重点介绍了静态和动态 DNA 纳米结构的设计和制造方面的最新进展，以及这些纳米结构在各种类型药物输送中的应用。还证明了动态 DNA 纳米结构提供了实现逻辑控制药物释放所需的智能。
