Ekiz Ozlem, Balta Ilknur, Sen Bilge Bülbül, Dikilitaş Meltem Cik, Ozuğuz Pınar, Rifaioğlu Emine Nur
Department of Dermatology, Mustafa Kemal University, Tayfur Ata Sokmen Medical School , Hatay , Turkey .
Cutan Ocul Toxicol. 2014 Mar;33(1):60-2. doi: 10.3109/15569527.2013.797907. Epub 2013 May 28.
Rosacea is a common chronic skin condition affecting the face. In recent years, significant evidence shows that vitamin D plays an important role in modulating the immune system. Vitamin D and its analogues via these mechanisms are playing an increasing role in the management of atopic dermatitis, psoriasis, vitiligo, acne and rosacea.
In our study, we aimed to investigate the relationship between serum vitamin D levels in patients with rosacea and analyze the association of vitamin D with clinical features.
Forty-four rosacea patients and 32 healthy control subjects were included into the study. 25-hydroxyvitamin D (25(OH)D), calcium and intact parathyroid hormone were measured. Deficiency of vitamin D is defined as the level of 25(OH)D being less than 20 ng/ml.
Thirty-three female and 11 male patients were included in the study. The mean age of patients was 48.6 ± 11.5. The mean levels of vitamin D levels were found as 21.4 ± 9.9 and 17.1 ± 7.9 in patients and controls, respectively. The difference was statistically significant (p = 0.04). The prevalence of vitamin D deficiency in patients with rosacea was 38.6% and 28.1% in healthy controls (p = 0.34).
To the best of our knowledge, our study is the first study for evaluating serum vitamin D levels of patients with rosacea in the literature. Patients with rosacea have relatively high serum vitamin D levels compared to control groups. The result of our study suggests that increased vitamin D levels may lead to the development of rosacea. To confirm status of vitamin D levels in patients with rosacea, larger epidemiological studies are needed.
酒渣鼻是一种影响面部的常见慢性皮肤病。近年来，大量证据表明维生素D在调节免疫系统中起重要作用。维生素D及其类似物通过这些机制在特应性皮炎、银屑病、白癜风、痤疮和酒渣鼻的治疗中发挥着越来越重要的作用。
在我们的研究中，我们旨在调查酒渣鼻患者血清维生素D水平之间的关系，并分析维生素D与临床特征的关联。
44名酒渣鼻患者和32名健康对照者纳入研究。检测25-羟维生素D（25(OH)D）、钙和完整甲状旁腺激素。维生素D缺乏定义为25(OH)D水平低于20 ng/ml。
研究纳入33名女性和11名男性患者。患者的平均年龄为48.6±11.5岁。患者和对照组的维生素D平均水平分别为21.4±9.9和17.1±7.9。差异具有统计学意义（p = 0.04）。酒渣鼻患者维生素D缺乏的患病率为38.6%，健康对照者为28.1%（p = 0.34）。
据我们所知，我们的研究是文献中第一项评估酒渣鼻患者血清维生素D水平的研究。与对照组相比，酒渣鼻患者的血清维生素D水平相对较高。我们的研究结果表明，维生素D水平升高可能导致酒渣鼻的发生。为了证实酒渣鼻患者维生素D水平的状况，需要进行更大规模的流行病学研究。
