多价性增强了缓激肽衍生肽对脂质纳米囊泡的选择性和亲和力。
Multivalency amplifies the selection and affinity of bradykinin-derived peptides for lipid nanovesicles.
作者信息
Saludes Jonel P, Morton Leslie A, Coulup Sara K, Fiorini Zeno, Cook Brandan M, Beninson Lida, Chapman Edwin R, Fleshner Monika, Yin Hang
机构信息
Department of Chemistry & Biochemistry and BioFrontiers Institute, University of Colorado, Boulder, CO 80309, USA.
出版信息
Mol Biosyst. 2013 Aug;9(8):2005-9. doi: 10.1039/c3mb70109c. Epub 2013 May 28.
Abstract
The trimer of a bradykinin derivative displayed a more than five-fold increase in binding affinity for phosphatidylserine-enriched nanovesicles as compared to its monomeric precursor. The nanovesicle selection is directly correlated with multivalency, which amplifies the electrostatic attraction. This strategy may lead to the development of novel molecular probes for detecting highly curved membrane bilayers.
摘要
与单体前体相比，缓激肽衍生物的三聚体对富含磷脂酰丝氨酸的纳米囊泡的结合亲和力增加了五倍以上。纳米囊泡的选择与多价性直接相关，多价性增强了静电吸引力。该策略可能会导致开发用于检测高度弯曲膜双层的新型分子探针。
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