Laboratory of Cardio-Circulatory, Respiratory, Metabolic and Hormonal Adaptations to Muscular Exercise, Faculty of Medicine Ibn El Jazzar, Sousse, Tunisia,
Inflammation. 2013 Dec;36(6):1239-47. doi: 10.1007/s10753-013-9661-8.
The purpose of this study was to investigate the effect of 6 months aerobic exercise and diet alone or in combination on markers of inflammation (MOI) in circulation and in adipose abdominal tissue (AT) in obese women. Thirty obese subjects were randomized into a 24-week intervention: (1) exercise (EX), (2) diet (DI), and (3) exercise and diet (EXD). Blood samples were collected at baseline, after 12 and 24 weeks. AT biopsies were obtained only at baseline and after 24 weeks. In the EXD and DI groups, the fat loss was after 12 weeks was -13.74 and -7.8 % (P < 0.01) and after 24 weeks was -21.82 and -17 % (P < 0.01) with no changes in the EX group. After 12 and 24 weeks, maximal oxygen consumption (VO2max) was increased by 21.81-39.54 % (P < 0.05) in the EXD group and 18.09-40.95 % in the EX group with no changes in the DI group. In the EXD and DI groups, circulating levels of tumor necrosis factor α and interleukin 6 were decreased after 24 weeks for both groups (P < 0.01). No changes in the EX group. Homeostatic model assessment for insulin resistance decreased (P < 0.05) only after 24 weeks in the EXD group. In AT biopsies, subjects in the EXD and DI groups exhibited a significant decrease in MO (P < 0.01 for all). No changes in AT biopsies were found in the EX group. In conclusion, chronic aerobic exercise was found to have no effects on circulating and AT MOI despite an increased VO2max. Rather important body composition modifications were found to have beneficial effects on circulating and AT MOI in these obese women.
这项研究的目的是调查 6 个月的有氧运动和饮食单独或联合对肥胖女性循环和腹部脂肪组织（AT）中炎症标志物（MOI）的影响。30 名肥胖受试者被随机分为 24 周的干预组：（1）运动（EX），（2）饮食（DI）和（3）运动和饮食（EXD）。在基线、12 周和 24 周时采集血样。仅在基线和 24 周时采集 AT 活检。在 EXD 和 DI 组中，12 周和 24 周后脂肪损失分别为-13.74%和-7.8%（P<0.01）和-21.82%和-17%（P<0.01），而 EX 组没有变化。在 12 周和 24 周时，EXD 组的最大摄氧量（VO2max）增加了 21.81-39.54%（P<0.05），EX 组增加了 18.09-40.95%，而 DI 组没有变化。在 EXD 和 DI 组中，循环肿瘤坏死因子-α和白细胞介素 6 水平在 24 周后均下降（均为 P<0.01）。EX 组没有变化。仅在 EXD 组中，胰岛素抵抗的稳态模型评估（HOMA-IR）在 24 周后下降（P<0.05）。在 AT 活检中，EXD 和 DI 组的受试者 MO 显著下降（均为 P<0.01）。EX 组的 AT 活检没有变化。总之，尽管 VO2max 增加，但慢性有氧运动对循环和 AT MOI 没有影响。在这些肥胖女性中，重要的身体成分改变对循环和 AT MOI 有有益的影响。
