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可编程分形纳米结构界面用于癌细胞的特异性识别和电化学释放。

Programmable fractal nanostructured interfaces for specific recognition and electrochemical release of cancer cells.

机构信息

Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China; University of the Chinese Academy of Sciences, Beijing 100049, P. R. China.

出版信息

Adv Mater. 2013 Jul 12;25(26):3566-70. doi: 10.1002/adma.201300888. Epub 2013 May 29.

DOI:10.1002/adma.201300888
PMID:23716475
Abstract

Topographic recognition of cancer cells is triggered by fractal gold nanostructures (FAuNSs), leading to dramatically enhanced recognition capability and efficient release of cancer cells with little damage. The unique characteristic of FAuNSs is the similar fractal dimension of their surface and that of a cancer cell. The design of fractal nanostructures will open up opportunities for functional design of bio-interfaces for highly efficient recognition and release of disease-related rare cells, which will improve detection in a clinical environment.

摘要

分形金纳米结构(FAuNSs)触发癌细胞的地形识别,从而显著提高识别能力,并在几乎不造成损伤的情况下有效释放癌细胞。FAuNSs 的独特特征是其表面和癌细胞的分形维数相似。分形纳米结构的设计将为生物界面的功能设计开辟机会,以实现对与疾病相关的稀有细胞的高效识别和释放,从而提高临床环境中的检测水平。

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