Center for Advanced Genomic Technology, Bioinformatics Program, Boston University, Boston, MA 02215, USA.
Nucleic Acids Res. 2013 Jul;41(Web Server issue):W225-31. doi: 10.1093/nar/gkt401. Epub 2013 May 28.
With the rapid accumulation of our knowledge on diseases, disease-related genes and drug targets, network-based analysis plays an increasingly important role in systems biology, systems pharmacology and translational science. The new release of VisANT aims to provide new functions to facilitate the convenient network analysis of diseases, therapies, genes and drugs. With improved understanding of the mechanisms of complex diseases and drug actions through network analysis, novel drug methods (e.g., drug repositioning, multi-target drug and combination therapy) can be designed. More specifically, the new update includes (i) integrated search and navigation of disease and drug hierarchies; (ii) integrated disease-gene, therapy-drug and drug-target association to aid the network construction and filtering; (iii) annotation of genes/drugs using disease/therapy information; (iv) prediction of associated diseases/therapies for a given set of genes/drugs using enrichment analysis; (v) network transformation to support construction of versatile network of drugs, genes, diseases and therapies; (vi) enhanced user interface using docking windows to allow easy customization of node and edge properties with build-in legend node to distinguish different node type. VisANT is freely available at: http://visant.bu.edu.
随着我们对疾病、疾病相关基因和药物靶点知识的快速积累，基于网络的分析在系统生物学、系统药理学和转化科学中发挥着越来越重要的作用。VisANT 的新版本旨在提供新功能，以方便疾病、疗法、基因和药物的网络分析。通过网络分析更好地了解复杂疾病和药物作用的机制，可以设计新的药物方法（例如，药物重定位、多靶药物和联合治疗）。更具体地说，新的更新包括 (i) 疾病和药物层次结构的集成搜索和导航；(ii) 疾病-基因、治疗-药物和药物-靶点关联的集成，以辅助网络构建和过滤；(iii) 使用疾病/治疗信息注释基因/药物；(iv) 使用富集分析预测给定基因/药物集的相关疾病/疗法；(v) 网络转换以支持构建多样化的药物、基因、疾病和治疗网络；(vi) 使用停靠窗口增强用户界面，允许使用内置图例节点轻松自定义节点和边缘属性，以区分不同的节点类型。VisANT 可免费获得：http://visant.bu.edu。
