Rachidi Samar, Awada Sanaa, Al-Hajje Amal, Bawab Wafaa, Zein Salam, Saleh Nadine, Salameh Pascale
Laboratory of Epidemiological and Clinical Research, Lebanese University, Beirut, Lebanon.
Drug Healthc Patient Saf. 2013 May 15;5:123-31. doi: 10.2147/DHPS.S44525. Print 2013.
The harmful effects of medication and licit substance use during pregnancy may potentially constitute a major public health concern. Our study aims to assess risky exposure of Lebanese pregnant women to drugs, tobacco, caffeine, and alcohol, and to determine their effect on postnatal outcomes.
Women at term were addressed after delivery in five university hospitals of Beirut and Mount Lebanon between February and June 2012. A standardized questionnaire was administered to them. Moreover, medical files of both mothers and their respective newborns were checked to confirm information given by mothers, and to assess the health outcome of the babies.
Among the interviewed 350 women, active and passive smoking of tobacco (cigarette or water pipe), and consumption of category C, D, and X drugs were common during pregnancy in Lebanon; they were shown to negatively affect the neonatal outcome in multivariate analyses: they significantly decreased Apgar scores and increased the risk of underweight and medical complications of babies (P < 0.05).
Our study demonstrated that Lebanese women were exposed during pregnancy to multiple medications and licit substances that affected the neonates' health. Our findings have implications for clinical obstetric practice and prevention programs in Lebanon. Efforts should be made to decrease exposure to harmful substances during pregnancy.
孕期用药及使用合法物质的有害影响可能会成为一个重大的公共卫生问题。我们的研究旨在评估黎巴嫩孕妇接触毒品、烟草、咖啡因和酒精的风险，并确定其对产后结局的影响。
2012年2月至6月期间，在贝鲁特和黎巴嫩山的五所大学医院对足月分娩后的妇女进行了调查。向她们发放了一份标准化问卷。此外，检查了母亲及其新生儿的病历，以确认母亲提供的信息，并评估婴儿的健康状况。
在接受采访的350名妇女中，在黎巴嫩，孕期主动和被动吸烟（香烟或水烟）以及使用C类、D类和X类药物的情况很常见；多因素分析显示，这些行为会对新生儿结局产生负面影响：它们会显著降低阿氏评分，并增加婴儿体重不足和出现医疗并发症的风险（P<0.05）。
我们的研究表明，黎巴嫩妇女在孕期接触了多种影响新生儿健康的药物和合法物质。我们的研究结果对黎巴嫩的临床产科实践和预防项目具有启示意义。应努力减少孕期接触有害物质的情况。
