Nikolic S B, Abhayaratna W P, Leano R, Stowasser M, Sharman J E
Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia.
J Hum Hypertens. 2014 Jan;28(1):56-61. doi: 10.1038/jhh.2013.38. Epub 2013 May 30.
Office blood pressure (BP) is recommended to be measured after 5 min of seated rest, but it may decrease for 10 min of seated rest. This study aimed to determine the change (and its clinical relevance) in brachial and central BP from 5 to 10 min of seated rest. Office brachial and central BP (measured after 5 and 10 min), left ventricular (LV) mass index, 7-day home and ambulatory BP were measured in 250 participants with treated hypertension. Office brachial and central BP were significantly lower at 10-min compared with 5-min BP (P<0.001). Seven-day home systolic BP (SBP) was significantly lower than office SBP measured at 5 min (P<0.001), but was similar to office SBP at 10 min (P=0.511). From 5 to 10 min, the percentage of participants with controlled BP increased and the percentage of participants with high central pulse pressure (PP) decreased (P<0.001). Moreover, brachial and central PP were significantly correlated with LV mass index measured at 10 min (r=0.171, P=0.006 and r=0.139, P=0.027, respectively), but not at 5 min (r=0.115, P=0.068 and r=0.084, P=0.185, respectively). BP recorded after 10 min is more representative of true BP control. These findings have relevance to appropriate diagnosis of hypertension and design of clinical trials.
建议在坐位休息5分钟后测量诊室血压（BP），但坐位休息10分钟时血压可能会下降。本研究旨在确定坐位休息5至10分钟时肱动脉血压和中心动脉血压的变化（及其临床意义）。对250例接受治疗的高血压患者测量了诊室肱动脉血压和中心动脉血压（在5分钟和10分钟后测量）、左心室（LV）质量指数、7天家庭血压和动态血压。与5分钟时的血压相比，10分钟时的诊室肱动脉血压和中心动脉血压显著降低（P<0.001）。7天家庭收缩压（SBP）显著低于5分钟时测量的诊室SBP（P<0.001），但与10分钟时的诊室SBP相似（P=0.511）。从5分钟到10分钟，血压得到控制的参与者百分比增加，中心脉压（PP）高的参与者百分比下降（P<0.001）。此外，肱动脉和中心PP与10分钟时测量的LV质量指数显著相关（分别为r=0.171，P=0.006和r=0.139，P=0.027），但与5分钟时不相关（分别为r=0.115，P=0.068和r=0.084，P=0.185）。10分钟后记录的血压更能代表真正的血压控制情况。这些发现与高血压的正确诊断和临床试验设计相关。
